The anti-malarial chloroquine overcomes Primary resistance and restores sensitivity to Trastuzumab in HER2-positive breast cancer

Autophagy may control the de novo refractoriness of HER2 gene-amplified breast carcinomas to the monoclonal antibody trastuzumab (Herceptin). Tumor cells originally obtained from a patient who rapidly progressed on trastuzumab ab initio display increased cellular levels of the LC3-II protein—a findi...

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Detalles Bibliográficos
Autores principales: Cufí, Sílvia, Vazquez-Martin, Alejandro, Oliveras-Ferraros, Cristina, Corominas-Faja, Bruna, Cuyàs, Elisabet, López-Bonet, Eugeni, Martin-Castillo, Begoña, Joven, Jorge, Menendez, Javier A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749547/
https://www.ncbi.nlm.nih.gov/pubmed/23965851
http://dx.doi.org/10.1038/srep02469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749547/
https://www.ncbi.nlm.nih.gov/pubmed/23965851
http://dx.doi.org/10.1038/srep02469

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