Pazopanib and sunitinib trigger autophagic and non-autophagic death of bladder tumour cells

BACKGROUND: Tyrosine kinase inhibitors (TKI) such as sunitinib and pazopanib display their efficacy in a variety of solid tumours. However, their use in therapy is limited by the lack of evidence about the ability to induce cell death in cancer cells. Our aim was to evaluate cytotoxic effects induce...

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Detalles Bibliográficos
Autores principales: Santoni, M, Amantini, C, Morelli, M B, Liberati, S, Farfariello, V, Nabissi, M, Bonfili, L, Eleuteri, A M, Mozzicafreddo, M, Burattini, L, Berardi, R, Cascinu, S, Santoni, G
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749583/
https://www.ncbi.nlm.nih.gov/pubmed/23887605
http://dx.doi.org/10.1038/bjc.2013.420

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