A novel approach to generate a recombinant toxoid vaccine against Clostridium difficile

The Clostridium difficile toxins A and B are primarily responsible for symptoms of C. difficile associated disease and are prime targets for vaccine development. We describe a plasmid-based system for the production of genetically modified toxins in a non-sporulating strain of C. difficile that lack...

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Detalles Bibliográficos
Autores principales: Donald, Robert G. K., Flint, Mike, Kalyan, Narender, Johnson, Erik, Witko, Susan E., Kotash, Cheryl, Zhao, Ping, Megati, Shakuntala, Yurgelonis, Irina, Lee, Phillip Kwok, Matsuka, Yury V., Severina, Elena, Deatly, Anne, Sidhu, Mini, Jansen, Kathrin U., Minton, Nigel P., Anderson, Annaliesa S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for General Microbiology 2013
Materias:
Synthetic Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749728/
https://www.ncbi.nlm.nih.gov/pubmed/23629868
http://dx.doi.org/10.1099/mic.0.066712-0

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