Evolutionarily conserved structural changes in phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) isoforms are responsible for differences in enzyme activity and localization

Mammals have genes coding for three PI5P4Ks (PtdIns5P 4-kinases), and these have different cellular localizations, tissue distributions and lipid kinase activities. We describe in the present paper a detailed molecular exploration of human PI5P4Ks α, β and γ, as well as their fly and worm homologues...

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Detalles Bibliográficos
Autores principales: Clarke, Jonathan H., Irvine, Robin F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749867/
https://www.ncbi.nlm.nih.gov/pubmed/23758345
http://dx.doi.org/10.1042/BJ20130488

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749867/
https://www.ncbi.nlm.nih.gov/pubmed/23758345
http://dx.doi.org/10.1042/BJ20130488

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