Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels

Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1-antitrypsin (AAT) in the blood. Since low AAT serum levels fail to protect pulmonary tissue from enzymatic degradation, these polymorphisms also increase the risk for early onset c...

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Detalles Bibliográficos
Autores principales: Thun, Gian Andri, Imboden, Medea, Ferrarotti, Ilaria, Kumar, Ashish, Obeidat, Ma'en, Zorzetto, Michele, Haun, Margot, Curjuric, Ivan, Couto Alves, Alexessander, Jackson, Victoria E., Albrecht, Eva, Ried, Janina S., Teumer, Alexander, Lopez, Lorna M., Huffman, Jennifer E., Enroth, Stefan, Bossé, Yohan, Hao, Ke, Timens, Wim, Gyllensten, Ulf, Polasek, Ozren, Wilson, James F., Rudan, Igor, Hayward, Caroline, Sandford, Andrew J., Deary, Ian J., Koch, Beate, Reischl, Eva, Schulz, Holger, Hui, Jennie, James, Alan L., Rochat, Thierry, Russi, Erich W., Jarvelin, Marjo-Riitta, Strachan, David P., Hall, Ian P., Tobin, Martin D., Dahl, Morten, Fallgaard Nielsen, Sune, Nordestgaard, Børge G., Kronenberg, Florian, Luisetti, Maurizio, Probst-Hensch, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749935/
https://www.ncbi.nlm.nih.gov/pubmed/23990791
http://dx.doi.org/10.1371/journal.pgen.1003585

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