The Intronic Long Noncoding RNA ANRASSF1 Recruits PRC2 to the RASSF1A Promoter, Reducing the Expression of RASSF1A and Increasing Cell Proliferation

The down-regulation of the tumor-suppressor gene RASSF1A has been shown to increase cell proliferation in several tumors. RASSF1A expression is regulated through epigenetic events involving the polycomb repressive complex 2 (PRC2); however, the molecular mechanisms modulating the recruitment of this...

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Detalles Bibliográficos
Autores principales: Beckedorff, Felipe C., Ayupe, Ana C., Crocci-Souza, Renan, Amaral, Murilo S., Nakaya, Helder I., Soltys, Daniela T., Menck, Carlos F. M., Reis, Eduardo M., Verjovski-Almeida, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749938/
https://www.ncbi.nlm.nih.gov/pubmed/23990798
http://dx.doi.org/10.1371/journal.pgen.1003705

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