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Histone Variant HTZ1 Shows Extensive Epistasis with, but Does Not Increase Robustness to, New Mutations
Biological systems produce phenotypes that appear to be robust to perturbation by mutations and environmental variation. Prior studies identified genes that, when impaired, reveal previously cryptic genetic variation. This result is typically interpreted as evidence that the disrupted gene normally...
Autores principales: | Richardson, Joshua B., Uppendahl, Locke D., Traficante, Maria K., Levy, Sasha F., Siegal, Mark L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749942/ https://www.ncbi.nlm.nih.gov/pubmed/23990806 http://dx.doi.org/10.1371/journal.pgen.1003733 |
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