Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans

Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defe...

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Autores principales: Liu, Feng, He, Chen-Xi, Luo, Li-Jun, Zou, Quan-Li, Zhao, Yong-Xu, Saini, Ratni, Han, San-Feng, Knölker, Hans-Joachim, Wang, Li-Shun, Ge, Bao-Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749966/
https://www.ncbi.nlm.nih.gov/pubmed/23990780
http://dx.doi.org/10.1371/journal.ppat.1003545
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author Liu, Feng
He, Chen-Xi
Luo, Li-Jun
Zou, Quan-Li
Zhao, Yong-Xu
Saini, Ratni
Han, San-Feng
Knölker, Hans-Joachim
Wang, Li-Shun
Ge, Bao-Xue
author_facet Liu, Feng
He, Chen-Xi
Luo, Li-Jun
Zou, Quan-Li
Zhao, Yong-Xu
Saini, Ratni
Han, San-Feng
Knölker, Hans-Joachim
Wang, Li-Shun
Ge, Bao-Xue
author_sort Liu, Feng
collection PubMed
description Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway.
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spelling pubmed-37499662013-08-29 Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans Liu, Feng He, Chen-Xi Luo, Li-Jun Zou, Quan-Li Zhao, Yong-Xu Saini, Ratni Han, San-Feng Knölker, Hans-Joachim Wang, Li-Shun Ge, Bao-Xue PLoS Pathog Research Article Nuclear hormone receptors respond to small molecules such as retinoids or steroids and regulate development. Signaling in the conserved p38/PMK-1 MAP kinase pathway regulates innate immunity. In this study, we show that the Caenorhabditis elegans nuclear receptor DAF-12 negatively regulates the defense against pathogens via the downstream let-7 family of microRNAs, which directly target SKN-1, a gene downstream of PMK-1. These findings identify nuclear hormone receptors as components of innate immunity that crosstalk with the p38/PMK-1 MAP kinase pathway. Public Library of Science 2013-08-22 /pmc/articles/PMC3749966/ /pubmed/23990780 http://dx.doi.org/10.1371/journal.ppat.1003545 Text en © 2013 Liu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Liu, Feng
He, Chen-Xi
Luo, Li-Jun
Zou, Quan-Li
Zhao, Yong-Xu
Saini, Ratni
Han, San-Feng
Knölker, Hans-Joachim
Wang, Li-Shun
Ge, Bao-Xue
Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title_full Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title_fullStr Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title_full_unstemmed Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title_short Nuclear Hormone Receptor Regulation of MicroRNAs Controls Innate Immune Responses in C. elegans
title_sort nuclear hormone receptor regulation of micrornas controls innate immune responses in c. elegans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3749966/
https://www.ncbi.nlm.nih.gov/pubmed/23990780
http://dx.doi.org/10.1371/journal.ppat.1003545
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