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Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population
BACKGROUND/AIMS: Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 pol...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750035/ https://www.ncbi.nlm.nih.gov/pubmed/23990947 http://dx.doi.org/10.1371/journal.pone.0071382 |
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author | Migita, Kiyoshi Nakamura, Minoru Abiru, Seigo Jiuchi, Yuka Nagaoka, Shinya Komori, Atsumasa Hashimoto, Satoru Bekki, Shigemune Yamasaki, Kazumi Komatsu, Tatsuji Shimada, Masaaki Kouno, Hiroshi Hijioka, Taizo Kohjima, Motoyuki Nakamuta, Makoto Kato, Michio Yoshizawa, Kaname Ohta, Hajime Nakamura, Yoko Takezaki, Eiichi Nishimura, Hideo Sato, Takeaki Ario, Keisuke Hirashima, Noboru Oohara, Yukio Naganuma, Atsushi Muro, Toyokichi Sakai, Hironori Mita, Eiji Sugi, Kazuhiro Yamashita, Haruhiro Makita, Fujio Yatsuhashi, Hiroshi Ishibashi, Hiromi Yasunami, Michio |
author_facet | Migita, Kiyoshi Nakamura, Minoru Abiru, Seigo Jiuchi, Yuka Nagaoka, Shinya Komori, Atsumasa Hashimoto, Satoru Bekki, Shigemune Yamasaki, Kazumi Komatsu, Tatsuji Shimada, Masaaki Kouno, Hiroshi Hijioka, Taizo Kohjima, Motoyuki Nakamuta, Makoto Kato, Michio Yoshizawa, Kaname Ohta, Hajime Nakamura, Yoko Takezaki, Eiichi Nishimura, Hideo Sato, Takeaki Ario, Keisuke Hirashima, Noboru Oohara, Yukio Naganuma, Atsushi Muro, Toyokichi Sakai, Hironori Mita, Eiji Sugi, Kazuhiro Yamashita, Haruhiro Makita, Fujio Yatsuhashi, Hiroshi Ishibashi, Hiromi Yasunami, Michio |
author_sort | Migita, Kiyoshi |
collection | PubMed |
description | BACKGROUND/AIMS: Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 460 individuals of Japanese origin including 230 patients with type-1 autoimmune hepatitis and 230 healthy controls was analyzed for two single nucleotide polymorphisms in the STAT4 gene (rs7574865, rs7582694). The STAT4 rs7574865T allele conferred risk for type-1 autoimmune hepatitis (OR = 1.61, 95% CI = 1.23–2.11; P = 0.001), and patients without accompanying autoimmune diseases exhibited an association with the rs7574865T allele (OR = 1.50, 95%CI = 1.13–1.99; P = 0.005). Detailed genotype-phenotype analysis of type-1 autoimmune hepatitis patients with (n = 44) or without liver cirrhosis (n = 186) demonstrated that rs7574865 was not associated with the development of liver cirrhosis and phenotype (biochemical data and the presence of auto-antibodies). CONCLUSIONS/SIGNIFICANCE: This is the first study to show a positive association between a STAT4 polymorphism and type-1 autoimmune hepatitis, suggesting that autoimmune hepatitis shares a gene commonly associated with risk for other autoimmune diseases. |
format | Online Article Text |
id | pubmed-3750035 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37500352013-08-29 Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population Migita, Kiyoshi Nakamura, Minoru Abiru, Seigo Jiuchi, Yuka Nagaoka, Shinya Komori, Atsumasa Hashimoto, Satoru Bekki, Shigemune Yamasaki, Kazumi Komatsu, Tatsuji Shimada, Masaaki Kouno, Hiroshi Hijioka, Taizo Kohjima, Motoyuki Nakamuta, Makoto Kato, Michio Yoshizawa, Kaname Ohta, Hajime Nakamura, Yoko Takezaki, Eiichi Nishimura, Hideo Sato, Takeaki Ario, Keisuke Hirashima, Noboru Oohara, Yukio Naganuma, Atsushi Muro, Toyokichi Sakai, Hironori Mita, Eiji Sugi, Kazuhiro Yamashita, Haruhiro Makita, Fujio Yatsuhashi, Hiroshi Ishibashi, Hiromi Yasunami, Michio PLoS One Research Article BACKGROUND/AIMS: Recent studies demonstrated an association of STAT4 polymorphisms with autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis, indicating multiple autoimmune diseases share common susceptibility genes. We therefore investigated the influence of STAT4 polymorphisms on the susceptibility and phenotype of type-1 autoimmune hepatitis in a Japanese National Hospital Organization (NHO) AIH multicenter cohort study. METHODOLOGY/PRINCIPAL FINDINGS: Genomic DNA from 460 individuals of Japanese origin including 230 patients with type-1 autoimmune hepatitis and 230 healthy controls was analyzed for two single nucleotide polymorphisms in the STAT4 gene (rs7574865, rs7582694). The STAT4 rs7574865T allele conferred risk for type-1 autoimmune hepatitis (OR = 1.61, 95% CI = 1.23–2.11; P = 0.001), and patients without accompanying autoimmune diseases exhibited an association with the rs7574865T allele (OR = 1.50, 95%CI = 1.13–1.99; P = 0.005). Detailed genotype-phenotype analysis of type-1 autoimmune hepatitis patients with (n = 44) or without liver cirrhosis (n = 186) demonstrated that rs7574865 was not associated with the development of liver cirrhosis and phenotype (biochemical data and the presence of auto-antibodies). CONCLUSIONS/SIGNIFICANCE: This is the first study to show a positive association between a STAT4 polymorphism and type-1 autoimmune hepatitis, suggesting that autoimmune hepatitis shares a gene commonly associated with risk for other autoimmune diseases. Public Library of Science 2013-08-22 /pmc/articles/PMC3750035/ /pubmed/23990947 http://dx.doi.org/10.1371/journal.pone.0071382 Text en © 2013 Migita et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Migita, Kiyoshi Nakamura, Minoru Abiru, Seigo Jiuchi, Yuka Nagaoka, Shinya Komori, Atsumasa Hashimoto, Satoru Bekki, Shigemune Yamasaki, Kazumi Komatsu, Tatsuji Shimada, Masaaki Kouno, Hiroshi Hijioka, Taizo Kohjima, Motoyuki Nakamuta, Makoto Kato, Michio Yoshizawa, Kaname Ohta, Hajime Nakamura, Yoko Takezaki, Eiichi Nishimura, Hideo Sato, Takeaki Ario, Keisuke Hirashima, Noboru Oohara, Yukio Naganuma, Atsushi Muro, Toyokichi Sakai, Hironori Mita, Eiji Sugi, Kazuhiro Yamashita, Haruhiro Makita, Fujio Yatsuhashi, Hiroshi Ishibashi, Hiromi Yasunami, Michio Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title_full | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title_fullStr | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title_full_unstemmed | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title_short | Association of STAT4 Polymorphisms with Susceptibility to Type-1 Autoimmune Hepatitis in the Japanese Population |
title_sort | association of stat4 polymorphisms with susceptibility to type-1 autoimmune hepatitis in the japanese population |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750035/ https://www.ncbi.nlm.nih.gov/pubmed/23990947 http://dx.doi.org/10.1371/journal.pone.0071382 |
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