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Solvent effects on the structure-property relationship of anticonvulsant hydantoin derivatives: A solvatochromic analysis
Considering the pharmaceutical importance of hydantoins, a set of 25 derivatives of phenytoin, nirvanol and 5-methyl-5-phenylhydantoin, the lipophilicities of which were gradually increased by the introduction of different alkyl, cycloalkyl and alkenyl groups in position N3, was synthesized. Their p...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2011
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750111/ https://www.ncbi.nlm.nih.gov/pubmed/21999701 http://dx.doi.org/10.1186/1752-153X-5-62 |