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Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report

INTRODUCTION: With more than one-third of the world’s population living in areas at risk for transmission, dengue fever is a leading cause of illness and death in the tropics and subtropics. Despite the high incidence of dengue fever, rhabdomyolysis leading to acute renal failure is an extremely rar...

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Autores principales: Wijesinghe, Aruna, Gnanapragash, Nanthini, Ranasinghe, Gayan, Ragunathan, Murugapillai K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750229/
https://www.ncbi.nlm.nih.gov/pubmed/23889764
http://dx.doi.org/10.1186/1752-1947-7-195
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author Wijesinghe, Aruna
Gnanapragash, Nanthini
Ranasinghe, Gayan
Ragunathan, Murugapillai K
author_facet Wijesinghe, Aruna
Gnanapragash, Nanthini
Ranasinghe, Gayan
Ragunathan, Murugapillai K
author_sort Wijesinghe, Aruna
collection PubMed
description INTRODUCTION: With more than one-third of the world’s population living in areas at risk for transmission, dengue fever is a leading cause of illness and death in the tropics and subtropics. Despite the high incidence of dengue fever, rhabdomyolysis leading to acute renal failure is an extremely rare complication of dengue fever. Only a few such cases have been reported in the literature. CASE PRESENTATION: We describe the case of a 42-year-old, previously healthy Sri Lankan Sinhalese man who developed acute renal failure due to rhabdomyolysis following dengue virus infection. He was transferred to our institution with a five-day history of fever, headache, myalgia, impaired level of consciousness, and reduced urinary output. He was hemodynamically stable and did not have evidence of plasma leakage. His serology for dengue immunoglobulin M and immunoglobulin G was positive, and biochemical investigations disclosed evidence of rhabdomyolysis and acute renal failure. He was treated with induced alkaline diuresis and hemodialysis, and he experienced an uncomplicated recovery. CONCLUSION: The occurrence of acute renal failure significantly increases the mortality of patients with dengue fever. Therefore, early diagnosis and early management are crucial in rhabdomyolysis complicating dengue fever to prevent established acute renal failure. It should be kept in mind that the threshold for suspecting rhabdomyolysis is very low in dengue fever. Creatinine phosphokinase levels should routinely be measured in all patients with severe dengue fever for early detection of rhabdomyolysis to prevent acute renal failure.
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spelling pubmed-37502292013-08-24 Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report Wijesinghe, Aruna Gnanapragash, Nanthini Ranasinghe, Gayan Ragunathan, Murugapillai K J Med Case Rep Case Report INTRODUCTION: With more than one-third of the world’s population living in areas at risk for transmission, dengue fever is a leading cause of illness and death in the tropics and subtropics. Despite the high incidence of dengue fever, rhabdomyolysis leading to acute renal failure is an extremely rare complication of dengue fever. Only a few such cases have been reported in the literature. CASE PRESENTATION: We describe the case of a 42-year-old, previously healthy Sri Lankan Sinhalese man who developed acute renal failure due to rhabdomyolysis following dengue virus infection. He was transferred to our institution with a five-day history of fever, headache, myalgia, impaired level of consciousness, and reduced urinary output. He was hemodynamically stable and did not have evidence of plasma leakage. His serology for dengue immunoglobulin M and immunoglobulin G was positive, and biochemical investigations disclosed evidence of rhabdomyolysis and acute renal failure. He was treated with induced alkaline diuresis and hemodialysis, and he experienced an uncomplicated recovery. CONCLUSION: The occurrence of acute renal failure significantly increases the mortality of patients with dengue fever. Therefore, early diagnosis and early management are crucial in rhabdomyolysis complicating dengue fever to prevent established acute renal failure. It should be kept in mind that the threshold for suspecting rhabdomyolysis is very low in dengue fever. Creatinine phosphokinase levels should routinely be measured in all patients with severe dengue fever for early detection of rhabdomyolysis to prevent acute renal failure. BioMed Central 2013-07-26 /pmc/articles/PMC3750229/ /pubmed/23889764 http://dx.doi.org/10.1186/1752-1947-7-195 Text en Copyright © 2013 Wijesinghe et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Wijesinghe, Aruna
Gnanapragash, Nanthini
Ranasinghe, Gayan
Ragunathan, Murugapillai K
Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title_full Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title_fullStr Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title_full_unstemmed Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title_short Acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
title_sort acute renal failure due to rhabdomyolysis following dengue viral infection: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750229/
https://www.ncbi.nlm.nih.gov/pubmed/23889764
http://dx.doi.org/10.1186/1752-1947-7-195
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