The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality

Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes melli...

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Detalles Bibliográficos
Autores principales: Gustafsson, David, Unwin, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750299/
https://www.ncbi.nlm.nih.gov/pubmed/23895142
http://dx.doi.org/10.1186/1471-2369-14-164
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author Gustafsson, David
Unwin, Robert
author_facet Gustafsson, David
Unwin, Robert
author_sort Gustafsson, David
collection PubMed
description Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options.
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spelling pubmed-37502992013-08-24 The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality Gustafsson, David Unwin, Robert BMC Nephrol Review Uric acid is the end product of purine metabolism in humans. High levels are causative in gout and urolithiasis. Hyperuricaemia has also been implicated in the pathophysiology of hypertension, chronic kidney disease (CKD), congestive heart failure (CHF), the metabolic syndrome, type 2 diabetes mellitus (T2DM), and atherosclerosis, with or without cardiovascular events. This article briefly reviews uric acid metabolism and summarizes the current literature on hyperuricaemia in cardiovascular disease and related co-morbidities, and emerging treatment options. BioMed Central 2013-07-29 /pmc/articles/PMC3750299/ /pubmed/23895142 http://dx.doi.org/10.1186/1471-2369-14-164 Text en Copyright © 2013 Gustafsson and Unwin; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Gustafsson, David
Unwin, Robert
The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title_full The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title_fullStr The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title_full_unstemmed The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title_short The pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
title_sort pathophysiology of hyperuricaemia and its possible relationship to cardiovascular disease, morbidity and mortality
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750299/
https://www.ncbi.nlm.nih.gov/pubmed/23895142
http://dx.doi.org/10.1186/1471-2369-14-164
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