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Acquired Fanconi syndrome in patients with Legionella pneumonia
BACKGROUND: Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified. CASE PRESENTATION: We experienced two male cases of acquired Fanconi syndrome associated with Legionella pneumonia. The l...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750396/ https://www.ncbi.nlm.nih.gov/pubmed/23915094 http://dx.doi.org/10.1186/1471-2369-14-171 |
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author | Kinoshita-Katahashi, Naoko Fukasawa, Hirotaka Ishigaki, Sayaka Isobe, Shinsuke Imokawa, Shiro Fujigaki, Yoshihide Furuya, Ryuichi |
author_facet | Kinoshita-Katahashi, Naoko Fukasawa, Hirotaka Ishigaki, Sayaka Isobe, Shinsuke Imokawa, Shiro Fujigaki, Yoshihide Furuya, Ryuichi |
author_sort | Kinoshita-Katahashi, Naoko |
collection | PubMed |
description | BACKGROUND: Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified. CASE PRESENTATION: We experienced two male cases of acquired Fanconi syndrome associated with Legionella pneumonia. The laboratory findings at admission showed hypophosphatemia, hypokalemia, hypouricemia and/or hyponatremia. In addition, they had the generalized dysfunction of the renal proximal tubules presenting decreased tubular reabsorption of phosphate (%TRP), increased fractional excretion of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria. Therefore, they were diagnosed as Fanconi syndrome. Treatment for Legionella pneumonia with antibiotics resulted in the improvement of all serum electrolyte abnormalities and normalization of the %TRP, FEK, FEUA, low-molecular-weight proteinuria, panaminoaciduria and glycosuria, suggesting that Legionella pneumophila infection contributed to the pathophysiology of Fanconi syndrome. CONCLUSION: To the best of our knowledge, this is the first report demonstrating Fanconi syndrome associated with Legionella pneumonia. |
format | Online Article Text |
id | pubmed-3750396 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37503962013-08-24 Acquired Fanconi syndrome in patients with Legionella pneumonia Kinoshita-Katahashi, Naoko Fukasawa, Hirotaka Ishigaki, Sayaka Isobe, Shinsuke Imokawa, Shiro Fujigaki, Yoshihide Furuya, Ryuichi BMC Nephrol Case Report BACKGROUND: Hyponatremia is often observed in patients with Legionella pneumonia. However, other electrolyte abnormalities are uncommon and the mechanism remains to be clarified. CASE PRESENTATION: We experienced two male cases of acquired Fanconi syndrome associated with Legionella pneumonia. The laboratory findings at admission showed hypophosphatemia, hypokalemia, hypouricemia and/or hyponatremia. In addition, they had the generalized dysfunction of the renal proximal tubules presenting decreased tubular reabsorption of phosphate (%TRP), increased fractional excretion of potassium (FEK) and uric acid (FEUA), low-molecular-weight proteinuria, panaminoaciduria and glycosuria. Therefore, they were diagnosed as Fanconi syndrome. Treatment for Legionella pneumonia with antibiotics resulted in the improvement of all serum electrolyte abnormalities and normalization of the %TRP, FEK, FEUA, low-molecular-weight proteinuria, panaminoaciduria and glycosuria, suggesting that Legionella pneumophila infection contributed to the pathophysiology of Fanconi syndrome. CONCLUSION: To the best of our knowledge, this is the first report demonstrating Fanconi syndrome associated with Legionella pneumonia. BioMed Central 2013-08-02 /pmc/articles/PMC3750396/ /pubmed/23915094 http://dx.doi.org/10.1186/1471-2369-14-171 Text en Copyright © 2013 Kinoshita-Katahashi et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kinoshita-Katahashi, Naoko Fukasawa, Hirotaka Ishigaki, Sayaka Isobe, Shinsuke Imokawa, Shiro Fujigaki, Yoshihide Furuya, Ryuichi Acquired Fanconi syndrome in patients with Legionella pneumonia |
title | Acquired Fanconi syndrome in patients with Legionella pneumonia |
title_full | Acquired Fanconi syndrome in patients with Legionella pneumonia |
title_fullStr | Acquired Fanconi syndrome in patients with Legionella pneumonia |
title_full_unstemmed | Acquired Fanconi syndrome in patients with Legionella pneumonia |
title_short | Acquired Fanconi syndrome in patients with Legionella pneumonia |
title_sort | acquired fanconi syndrome in patients with legionella pneumonia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750396/ https://www.ncbi.nlm.nih.gov/pubmed/23915094 http://dx.doi.org/10.1186/1471-2369-14-171 |
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