Loss of Akt1 or Akt2 delays mammary tumor onset and suppresses tumor growth rate in MTB-IGFIR transgenic mice

BACKGROUND: Akt is a serine/threonine kinase that mediates signaling downstream of tyrosine kinase receptors like the type I insulin-like growth factor receptor (IGF-IR). In fact, we have previously shown that mammary tumors induced by elevated expression of the IGF-IR are associated with hyperactiv...

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Detalles Bibliográficos
Autores principales: Watson, Katrina L, Moorehead, Roger A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750479/
https://www.ncbi.nlm.nih.gov/pubmed/23919516
http://dx.doi.org/10.1186/1471-2407-13-375

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750479/
https://www.ncbi.nlm.nih.gov/pubmed/23919516
http://dx.doi.org/10.1186/1471-2407-13-375

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