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Crosslinking and mass spectrometry suggest that the isolated NTD domain dimer of Moloney murine leukemia virus integrase adopts a parallel arrangement in solution

BACKGROUND: Retroviral integrases (INs) catalyze the integration of viral DNA in the chromosomal DNA of the infected cell. This reaction requires the multimerization of IN to coordinate a nucleophilic attack of the 3’ ends of viral DNA at two staggered phosphodiester bonds on the recipient DNA. Seve...

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Detalles Bibliográficos
Autores principales:	Henriquez, Daniel R, Zhao, Caifeng, Zheng, Haiyan, Arbildua, José J, Acevedo, Mónica L, Roth, Monica J, Leon, Oscar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750625/ https://www.ncbi.nlm.nih.gov/pubmed/23844665 http://dx.doi.org/10.1186/1472-6807-13-14

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