Increased sphingosine-1-phosphate improves muscle regeneration in acutely injured mdx mice

BACKGROUND: Presently, there is no effective treatment for the lethal muscle wasting disease Duchenne muscular dystrophy (DMD). Here we show that increased sphingosine-1-phoshate (S1P) through direct injection or via the administration of the small molecule 2-acetyl-4(5)-tetrahydroxybutyl imidazole...

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Detalles Bibliográficos
Autores principales: Ieronimakis, Nicholas, Pantoja, Mario, Hays, Aislinn L, Dosey, Timothy L, Qi, Junlin, Fischer, Karin A, Hoofnagle, Andrew N, Sadilek, Martin, Chamberlain, Jeffrey S, Ruohola-Baker, Hannele, Reyes, Morayma
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3750760/
https://www.ncbi.nlm.nih.gov/pubmed/23915702
http://dx.doi.org/10.1186/2044-5040-3-20

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