Asbestos and erionite prime and activate the NLRP3 inflammasome that stimulates autocrine cytokine release in human mesothelial cells

BACKGROUND: Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS: We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causal...

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Detalles Bibliográficos
Autores principales: Hillegass, Jedd M, Miller, Jill M, MacPherson, Maximilian B, Westbom, Catherine M, Sayan, Mutlay, Thompson, Joyce K, Macura, Sherrill L, Perkins, Timothy N, Beuschel, Stacie L, Alexeeva, Vlada, Pass, Harvey I, Steele, Chad, Mossman, Brooke T, Shukla, Arti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751315/
https://www.ncbi.nlm.nih.gov/pubmed/23937860
http://dx.doi.org/10.1186/1743-8977-10-39

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