Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a

Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 singl...

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Autores principales: Xu, DeQi, Cisar, John O., Poly, Frédéric, Yang, Jinghua, Albanese, Jason, Dharmasena, Madushini, Wai, Tint, Guerry, Patricia, Kopecko, Dennis J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2013
Materias:
Prokaryotes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751609/
https://www.ncbi.nlm.nih.gov/pubmed/23969054
http://dx.doi.org/10.1128/genomeA.00650-13
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author Xu, DeQi
Cisar, John O.
Poly, Frédéric
Yang, Jinghua
Albanese, Jason
Dharmasena, Madushini
Wai, Tint
Guerry, Patricia
Kopecko, Dennis J.
author_facet Xu, DeQi
Cisar, John O.
Poly, Frédéric
Yang, Jinghua
Albanese, Jason
Dharmasena, Madushini
Wai, Tint
Guerry, Patricia
Kopecko, Dennis J.
author_sort Xu, DeQi
collection PubMed
description Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.
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spelling pubmed-37516092013-08-27 Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a Xu, DeQi Cisar, John O. Poly, Frédéric Yang, Jinghua Albanese, Jason Dharmasena, Madushini Wai, Tint Guerry, Patricia Kopecko, Dennis J. Genome Announc Prokaryotes Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity. American Society for Microbiology 2013-08-22 /pmc/articles/PMC3751609/ /pubmed/23969054 http://dx.doi.org/10.1128/genomeA.00650-13 Text en Copyright © 2013 Xu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 Unported license (http://creativecommons.org/licenses/by/3.0/) .
spellingShingle Prokaryotes
Xu, DeQi
Cisar, John O.
Poly, Frédéric
Yang, Jinghua
Albanese, Jason
Dharmasena, Madushini
Wai, Tint
Guerry, Patricia
Kopecko, Dennis J.
Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title_full Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title_fullStr Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title_full_unstemmed Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title_short Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
title_sort genome sequence of salmonella enterica serovar typhi oral vaccine strain ty21a
topic Prokaryotes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751609/
https://www.ncbi.nlm.nih.gov/pubmed/23969054
http://dx.doi.org/10.1128/genomeA.00650-13
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