Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia

The association of microRNA alterations with progression and treatment outcome has been revealed in different types of cancers. To find miRNAs involved in imatinib response we performed miRNA microarray followed by RT-qPCR verification of 9 available diagnostic bone marrow core biopsies from 9 CML p...

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Autores principales: Mosakhani, Neda, Mustjoki, Satu, Knuutila, Sakari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Letter to Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751646/
https://www.ncbi.nlm.nih.gov/pubmed/23866735
http://dx.doi.org/10.1186/1755-8166-6-27
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author Mosakhani, Neda
Mustjoki, Satu
Knuutila, Sakari
author_facet Mosakhani, Neda
Mustjoki, Satu
Knuutila, Sakari
author_sort Mosakhani, Neda
collection PubMed
description The association of microRNA alterations with progression and treatment outcome has been revealed in different types of cancers. To find miRNAs involved in imatinib response we performed miRNA microarray followed by RT-qPCR verification of 9 available diagnostic bone marrow core biopsies from 9 CML patients including 4 imatinib-resistant and 5 imatinib-responder patients. Only one differentially expressed miRNA, miR-181c, was found when the imatinib-resistant group was compared with imatinib-responders. Significant down-regulation of miR-181c in imatinib-resistant versus imatinib-responders was confirmed by qRT-PCR. Some miR-181c target genes such as PBX3, HSP90B1, NMT2 and RAD21 have been associated with drug response.
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spelling pubmed-37516462013-08-24 Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia Mosakhani, Neda Mustjoki, Satu Knuutila, Sakari Mol Cytogenet Letter to Editor The association of microRNA alterations with progression and treatment outcome has been revealed in different types of cancers. To find miRNAs involved in imatinib response we performed miRNA microarray followed by RT-qPCR verification of 9 available diagnostic bone marrow core biopsies from 9 CML patients including 4 imatinib-resistant and 5 imatinib-responder patients. Only one differentially expressed miRNA, miR-181c, was found when the imatinib-resistant group was compared with imatinib-responders. Significant down-regulation of miR-181c in imatinib-resistant versus imatinib-responders was confirmed by qRT-PCR. Some miR-181c target genes such as PBX3, HSP90B1, NMT2 and RAD21 have been associated with drug response. BioMed Central 2013-07-16 /pmc/articles/PMC3751646/ /pubmed/23866735 http://dx.doi.org/10.1186/1755-8166-6-27 Text en Copyright © 2013 Mosakhani et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Letter to Editor
Mosakhani, Neda
Mustjoki, Satu
Knuutila, Sakari
Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title_full Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title_fullStr Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title_full_unstemmed Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title_short Down-regulation of miR-181c in imatinib-resistant chronic myeloid leukemia
title_sort down-regulation of mir-181c in imatinib-resistant chronic myeloid leukemia
topic Letter to Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751646/
https://www.ncbi.nlm.nih.gov/pubmed/23866735
http://dx.doi.org/10.1186/1755-8166-6-27
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