Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

BACKGROUND: Cucurbitacins are a class of triterpenoid natural compounds with potent bioactivities that led to their use as traditional remedies, and which continue to attract considerable attention as chemical biology tools and potential therapeutics. One obvious target is the actin-cytoskeleton; tr...

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Detalles Bibliográficos
Autores principales: Gabrielsen, Mads, Schuldt, Maike, Munro, June, Borucka, Dagmara, Cameron, Jenifer, Baugh, Mark, Mleczak, Andrzej, Lilla, Sergio, Morrice, Nicholas, Olson, Michael F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751690/
https://www.ncbi.nlm.nih.gov/pubmed/23945128
http://dx.doi.org/10.1186/1478-811X-11-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751690/
https://www.ncbi.nlm.nih.gov/pubmed/23945128
http://dx.doi.org/10.1186/1478-811X-11-58

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