Cargando…
Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A to...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751760/ https://www.ncbi.nlm.nih.gov/pubmed/23953708 http://dx.doi.org/10.1186/1477-7819-11-201 |
_version_ | 1782281663329337344 |
---|---|
author | Yu, Junxiu Fu, Bo Zhao, Qi |
author_facet | Yu, Junxiu Fu, Bo Zhao, Qi |
author_sort | Yu, Junxiu |
collection | PubMed |
description | BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer’s V coefficient. RESULTS: Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109). CONCLUSIONS: More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients. |
format | Online Article Text |
id | pubmed-3751760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37517602013-08-24 Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients Yu, Junxiu Fu, Bo Zhao, Qi World J Surg Oncol Research BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer’s V coefficient. RESULTS: Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109). CONCLUSIONS: More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients. BioMed Central 2013-08-16 /pmc/articles/PMC3751760/ /pubmed/23953708 http://dx.doi.org/10.1186/1477-7819-11-201 Text en Copyright ©2013 Yu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Yu, Junxiu Fu, Bo Zhao, Qi Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title | Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title_full | Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title_fullStr | Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title_full_unstemmed | Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title_short | Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
title_sort | family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751760/ https://www.ncbi.nlm.nih.gov/pubmed/23953708 http://dx.doi.org/10.1186/1477-7819-11-201 |
work_keys_str_mv | AT yujunxiu familyhistoryofmalignantneoplasmanditsrelationwithclinicopathologicfeaturesofgastriccancerpatients AT fubo familyhistoryofmalignantneoplasmanditsrelationwithclinicopathologicfeaturesofgastriccancerpatients AT zhaoqi familyhistoryofmalignantneoplasmanditsrelationwithclinicopathologicfeaturesofgastriccancerpatients |