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Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients

BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A to...

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Autores principales: Yu, Junxiu, Fu, Bo, Zhao, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751760/
https://www.ncbi.nlm.nih.gov/pubmed/23953708
http://dx.doi.org/10.1186/1477-7819-11-201
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author Yu, Junxiu
Fu, Bo
Zhao, Qi
author_facet Yu, Junxiu
Fu, Bo
Zhao, Qi
author_sort Yu, Junxiu
collection PubMed
description BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer’s V coefficient. RESULTS: Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109). CONCLUSIONS: More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients.
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spelling pubmed-37517602013-08-24 Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients Yu, Junxiu Fu, Bo Zhao, Qi World J Surg Oncol Research BACKGROUND: Few studies to date have evaluated gastric cancer(GC)-related malignant neoplasm family history (MN-FH), and their findings have been largely inconsistent. The aim of this study is to evaluate the prevalence of MN-FH and its relation to the clinicopathologic features of GC. METHODS: A total of 104 hospitalized patients with primary gastric adenocarcinoma was prospectively analyzed from 2008 to 2009. Positive MN-FH was defined as MN-affected first- and second-degree relatives of the current GC cases. The relation between prevalence of positive MN-FH and clinicopathologic features in the current GC patients was assessed using the Chi-square test with Cramer’s V coefficient. RESULTS: Thirty-seven (35.6%) of the GC patients had positive MN-FH, with 42 associated tumors in first- and second-degree relatives. Twenty-six (61.9%) of the associated tumors were located in the digestive system, including the esophagus (26.2%), stomach (23.8%), liver (9.5%) and colon (2.4%). Lung cancers were the most prevalent non-digestive system-associated tumors (9.5%). Correlation analysis revealed no significant relations with prevalence of MN-FH and any of the clinicopathologic features (all, P > 0.05), including sex (V = 0.044), age (V = 0.060) and histological subtypes (V = 0.109). CONCLUSIONS: More than one-third of the GC patients in our hospital had positive MN-FH. The most frequent forms of MN-FH were esophageal cancer and GC. The prevalence of positive MN-FH was not correlated to any of the clinicopathologic features, including sex, age and histological subtypes in the study population of GC patients. BioMed Central 2013-08-16 /pmc/articles/PMC3751760/ /pubmed/23953708 http://dx.doi.org/10.1186/1477-7819-11-201 Text en Copyright ©2013 Yu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Yu, Junxiu
Fu, Bo
Zhao, Qi
Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title_full Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title_fullStr Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title_full_unstemmed Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title_short Family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
title_sort family history of malignant neoplasm and its relation with clinicopathologic features of gastric cancer patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751760/
https://www.ncbi.nlm.nih.gov/pubmed/23953708
http://dx.doi.org/10.1186/1477-7819-11-201
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