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Epigenetic changes: a common theme in acute myelogenous leukemogenesis
Acute myeloid leukemia (AML) is a rather common disease, characterized by the presence of a clonal population of hematopoietic progenitor cells with impaired differentiation. Although traditionally AML has been considered the result of genetic alterations, more recently experimental evidence have de...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751780/ https://www.ncbi.nlm.nih.gov/pubmed/23938080 http://dx.doi.org/10.1186/1756-8722-6-57 |
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author | Gutierrez, Soraya E Romero-Oliva, Francisco A |
author_facet | Gutierrez, Soraya E Romero-Oliva, Francisco A |
author_sort | Gutierrez, Soraya E |
collection | PubMed |
description | Acute myeloid leukemia (AML) is a rather common disease, characterized by the presence of a clonal population of hematopoietic progenitor cells with impaired differentiation. Although traditionally AML has been considered the result of genetic alterations, more recently experimental evidence have demonstrated that epigenetic modifications are important in development and maintenance of leukemia cells. In this review we summarize current scientific knowledge of epigenetic alterations involved in leukemogenesis. We also highlight the developing of new technological strategies that are based on epigenetic processes and have been registered as Patents of Inventions in the United Nations dependent World Intellectual Property Office (WIPO) and the main Patent offices worldwide. |
format | Online Article Text |
id | pubmed-3751780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-37517802013-08-24 Epigenetic changes: a common theme in acute myelogenous leukemogenesis Gutierrez, Soraya E Romero-Oliva, Francisco A J Hematol Oncol Review Acute myeloid leukemia (AML) is a rather common disease, characterized by the presence of a clonal population of hematopoietic progenitor cells with impaired differentiation. Although traditionally AML has been considered the result of genetic alterations, more recently experimental evidence have demonstrated that epigenetic modifications are important in development and maintenance of leukemia cells. In this review we summarize current scientific knowledge of epigenetic alterations involved in leukemogenesis. We also highlight the developing of new technological strategies that are based on epigenetic processes and have been registered as Patents of Inventions in the United Nations dependent World Intellectual Property Office (WIPO) and the main Patent offices worldwide. BioMed Central 2013-08-13 /pmc/articles/PMC3751780/ /pubmed/23938080 http://dx.doi.org/10.1186/1756-8722-6-57 Text en Copyright © 2013 Gutierrez and Romero-Oliva; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Gutierrez, Soraya E Romero-Oliva, Francisco A Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title | Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title_full | Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title_fullStr | Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title_full_unstemmed | Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title_short | Epigenetic changes: a common theme in acute myelogenous leukemogenesis |
title_sort | epigenetic changes: a common theme in acute myelogenous leukemogenesis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751780/ https://www.ncbi.nlm.nih.gov/pubmed/23938080 http://dx.doi.org/10.1186/1756-8722-6-57 |
work_keys_str_mv | AT gutierrezsorayae epigeneticchangesacommonthemeinacutemyelogenousleukemogenesis AT romeroolivafranciscoa epigeneticchangesacommonthemeinacutemyelogenousleukemogenesis |