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Metformin Induces Apoptosis through AMPK-Dependent Inhibition of UPR Signaling in ALL Lymphoblasts

The outcome of patients with resistant phenotypes of acute lymphoblastic leukemia (ALL) or those who relapse remains poor. We investigated the mechanism of cell death induced by metformin in Bp- and T-ALL cell models and primary cells, and show that metformin effectively induces apoptosis in ALL cel...

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Detalles Bibliográficos
Autores principales:	Leclerc, Gilles M., Leclerc, Guy J., Kuznetsov, Jeffim N., DeSalvo, Joanna, Barredo, Julio C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751848/ https://www.ncbi.nlm.nih.gov/pubmed/24009772 http://dx.doi.org/10.1371/journal.pone.0074420

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