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Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding
BACKGROUND: HIV-1 relies on the host ESCRTs for release from cells. HIV-1 Gag engages ESCRTs by directly binding TSG101 or Alix. ESCRTs also sort ubiquitinated membrane proteins through endosomes to facilitate their lysosomal degradation. The ability of ESCRTs to recognize and process ubiquitinated...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751857/ https://www.ncbi.nlm.nih.gov/pubmed/23895345 http://dx.doi.org/10.1186/1742-4690-10-79 |