Ubiquitin conjugation to Gag is essential for ESCRT-mediated HIV-1 budding

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BACKGROUND: HIV-1 relies on the host ESCRTs for release from cells. HIV-1 Gag engages ESCRTs by directly binding TSG101 or Alix. ESCRTs also sort ubiquitinated membrane proteins through endosomes to facilitate their lysosomal degradation. The ability of ESCRTs to recognize and process ubiquitinated...

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Detalles Bibliográficos
Autores principales: Sette, Paola, Nagashima, Kunio, Piper, Robert C, Bouamr, Fadila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751857/
https://www.ncbi.nlm.nih.gov/pubmed/23895345
http://dx.doi.org/10.1186/1742-4690-10-79

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