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Multiple keratoacanthomas developing in healing plaques of Psoriasis

A 22 year old male psoriatic patient presented with multiple reddish scaly plaques all over body. After hematological and biochemical investigations the patient was started on oral methotrexate 15 mg weekly. PASI score at the start of treatment was 26.2. After 3 months PASI dropped to 11.5, the dose...

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Autores principales: Relhan, Vineet, Sinha, Surabhi, Khurana, Nita, Garg, Vijay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752476/
https://www.ncbi.nlm.nih.gov/pubmed/23984234
http://dx.doi.org/10.4103/2229-5178.115517
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author Relhan, Vineet
Sinha, Surabhi
Khurana, Nita
Garg, Vijay K.
author_facet Relhan, Vineet
Sinha, Surabhi
Khurana, Nita
Garg, Vijay K.
author_sort Relhan, Vineet
collection PubMed
description A 22 year old male psoriatic patient presented with multiple reddish scaly plaques all over body. After hematological and biochemical investigations the patient was started on oral methotrexate 15 mg weekly. PASI score at the start of treatment was 26.2. After 3 months PASI dropped to 11.5, the dose of methotrexate was tapered to 7.5mg weekly and the patient was maintained on this dose and kept under monthly follow up. Four months later, the patient presented with reddish to hyperpigmented raised firm nodules having a central crater over the healing plaques of psoriasis. Few lesions showed self resolution over a period of 6-12 weeks. Histopathology of the lesion confirmed it to be Keratoacanthoma. We believe the most likely etiologic factors for the multiple KAs in our patient could be a genetic susceptibility stimulated by multiple causes.
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spelling pubmed-37524762013-08-27 Multiple keratoacanthomas developing in healing plaques of Psoriasis Relhan, Vineet Sinha, Surabhi Khurana, Nita Garg, Vijay K. Indian Dermatol Online J Case Report A 22 year old male psoriatic patient presented with multiple reddish scaly plaques all over body. After hematological and biochemical investigations the patient was started on oral methotrexate 15 mg weekly. PASI score at the start of treatment was 26.2. After 3 months PASI dropped to 11.5, the dose of methotrexate was tapered to 7.5mg weekly and the patient was maintained on this dose and kept under monthly follow up. Four months later, the patient presented with reddish to hyperpigmented raised firm nodules having a central crater over the healing plaques of psoriasis. Few lesions showed self resolution over a period of 6-12 weeks. Histopathology of the lesion confirmed it to be Keratoacanthoma. We believe the most likely etiologic factors for the multiple KAs in our patient could be a genetic susceptibility stimulated by multiple causes. Medknow Publications & Media Pvt Ltd 2013 /pmc/articles/PMC3752476/ /pubmed/23984234 http://dx.doi.org/10.4103/2229-5178.115517 Text en Copyright: © Indian Dermatology Online Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Relhan, Vineet
Sinha, Surabhi
Khurana, Nita
Garg, Vijay K.
Multiple keratoacanthomas developing in healing plaques of Psoriasis
title Multiple keratoacanthomas developing in healing plaques of Psoriasis
title_full Multiple keratoacanthomas developing in healing plaques of Psoriasis
title_fullStr Multiple keratoacanthomas developing in healing plaques of Psoriasis
title_full_unstemmed Multiple keratoacanthomas developing in healing plaques of Psoriasis
title_short Multiple keratoacanthomas developing in healing plaques of Psoriasis
title_sort multiple keratoacanthomas developing in healing plaques of psoriasis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752476/
https://www.ncbi.nlm.nih.gov/pubmed/23984234
http://dx.doi.org/10.4103/2229-5178.115517
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