Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway

We recently reported that paracrine Fibroblast Growth Factor 2 (FGF2) triggers senescence in Ras-driven Y1 and 3T3(Ras) mouse malignant cell lines. Here, we show that although FGF2 activates mitogenic pathways in these Ras-dependent malignant cells, it can block cell proliferation and cause a G2/M a...

Descripción completa

Detalles Bibliográficos
Autores principales: Salotti, Jacqueline, Dias, Matheus H., Koga, Marianna M., Armelin, Hugo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753234/
https://www.ncbi.nlm.nih.gov/pubmed/23991123
http://dx.doi.org/10.1371/journal.pone.0072582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753234/
https://www.ncbi.nlm.nih.gov/pubmed/23991123
http://dx.doi.org/10.1371/journal.pone.0072582

Ejemplares similares