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Fibroblast Growth Factor 2 Causes G2/M Cell Cycle Arrest in Ras-Driven Tumor Cells through a Src-Dependent Pathway

We recently reported that paracrine Fibroblast Growth Factor 2 (FGF2) triggers senescence in Ras-driven Y1 and 3T3(Ras) mouse malignant cell lines. Here, we show that although FGF2 activates mitogenic pathways in these Ras-dependent malignant cells, it can block cell proliferation and cause a G2/M a...

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Detalles Bibliográficos
Autores principales:	Salotti, Jacqueline, Dias, Matheus H., Koga, Marianna M., Armelin, Hugo A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753234/ https://www.ncbi.nlm.nih.gov/pubmed/23991123 http://dx.doi.org/10.1371/journal.pone.0072582

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