LDL Cholesterol Modulates Human CD34+ HSPCs through Effects on Proliferation and the IL-17 G-CSF Axis

BACKGROUND: Hypercholesterolemia plays a critical role in atherosclerosis. CD34+ CD45dim Lineage- hematopoietic stem/progenitor cells (HSPCs) give rise to the inflammatory cells linked to atherosclerosis. In mice, high cholesterol levels mobilize HSPCs into the bloodstream, and promote their differe...

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Detalles Bibliográficos
Autores principales: Cimato, Thomas R., Palka, Beth A., Lang, Jennifer K., Young, Rebeccah F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753239/
https://www.ncbi.nlm.nih.gov/pubmed/23991206
http://dx.doi.org/10.1371/journal.pone.0073861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753239/
https://www.ncbi.nlm.nih.gov/pubmed/23991206
http://dx.doi.org/10.1371/journal.pone.0073861

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