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Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice
A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal (GI) tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia (PIN) and microinvasive carcinoma in a mouse model. We found that anim...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753256/ https://www.ncbi.nlm.nih.gov/pubmed/23991210 http://dx.doi.org/10.1371/journal.pone.0073933 |
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author | Poutahidis, Theofilos Cappelle, Kelsey Levkovich, Tatiana Lee, Chung-Wei Doulberis, Michael Ge, Zhongming Fox, James G. Horwitz, Bruce H. Erdman, Susan E. |
author_facet | Poutahidis, Theofilos Cappelle, Kelsey Levkovich, Tatiana Lee, Chung-Wei Doulberis, Michael Ge, Zhongming Fox, James G. Horwitz, Bruce H. Erdman, Susan E. |
author_sort | Poutahidis, Theofilos |
collection | PubMed |
description | A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal (GI) tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia (PIN) and microinvasive carcinoma in a mouse model. We found that animals with a genetic predilection for dysregulation of wnt signaling, Apc (Min/+) mutant mice, were significantly susceptible to prostate cancer in an inflammation-dependent manner following infection with Helicobacter hepaticus. Further, early neoplasia observed in infected Apc (Min/+) mice was transmissible to uninfected mice by intraperitoneal injection of mesenteric lymph node (MLN) cells alone from H. hepaticus-infected mutant mice. Transmissibility of neoplasia was preventable by prior neutralization of inflammation using anti-TNF-α antibody in infected MLN donor mice. Taken together, these data confirm that systemic inflammation triggered by GI tract bacteria plays a pivotal role in tumorigenesis of the prostate gland. |
format | Online Article Text |
id | pubmed-3753256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-37532562013-08-29 Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice Poutahidis, Theofilos Cappelle, Kelsey Levkovich, Tatiana Lee, Chung-Wei Doulberis, Michael Ge, Zhongming Fox, James G. Horwitz, Bruce H. Erdman, Susan E. PLoS One Research Article A role for microbes has been suspected in prostate cancer but difficult to confirm in human patients. We show here that a gastrointestinal (GI) tract bacterial infection is sufficient to enhance prostate intraepithelial neoplasia (PIN) and microinvasive carcinoma in a mouse model. We found that animals with a genetic predilection for dysregulation of wnt signaling, Apc (Min/+) mutant mice, were significantly susceptible to prostate cancer in an inflammation-dependent manner following infection with Helicobacter hepaticus. Further, early neoplasia observed in infected Apc (Min/+) mice was transmissible to uninfected mice by intraperitoneal injection of mesenteric lymph node (MLN) cells alone from H. hepaticus-infected mutant mice. Transmissibility of neoplasia was preventable by prior neutralization of inflammation using anti-TNF-α antibody in infected MLN donor mice. Taken together, these data confirm that systemic inflammation triggered by GI tract bacteria plays a pivotal role in tumorigenesis of the prostate gland. Public Library of Science 2013-08-26 /pmc/articles/PMC3753256/ /pubmed/23991210 http://dx.doi.org/10.1371/journal.pone.0073933 Text en © 2013 Poutahidis et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Poutahidis, Theofilos Cappelle, Kelsey Levkovich, Tatiana Lee, Chung-Wei Doulberis, Michael Ge, Zhongming Fox, James G. Horwitz, Bruce H. Erdman, Susan E. Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title | Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title_full | Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title_fullStr | Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title_full_unstemmed | Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title_short | Pathogenic Intestinal Bacteria Enhance Prostate Cancer Development via Systemic Activation of Immune Cells in Mice |
title_sort | pathogenic intestinal bacteria enhance prostate cancer development via systemic activation of immune cells in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753256/ https://www.ncbi.nlm.nih.gov/pubmed/23991210 http://dx.doi.org/10.1371/journal.pone.0073933 |
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