Cargando…

Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition

The purpose of this study was to test the hypothesis that higher levels of systemic inflammation in a community sample of non-demented subjects older than seventy years of age are associated with reduced diffusion anisotropy in brain white matter and lower cognition. Ninety-five older persons withou...

Descripción completa

Detalles Bibliográficos
Autores principales: Arfanakis, Konstantinos, Fleischman, Debra A., Grisot, Giorgia, Barth, Christopher M., Varentsova, Anna, Morris, Martha C., Barnes, Lisa L., Bennett, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753267/
https://www.ncbi.nlm.nih.gov/pubmed/23991174
http://dx.doi.org/10.1371/journal.pone.0073107
_version_ 1782281804411043840
author Arfanakis, Konstantinos
Fleischman, Debra A.
Grisot, Giorgia
Barth, Christopher M.
Varentsova, Anna
Morris, Martha C.
Barnes, Lisa L.
Bennett, David A.
author_facet Arfanakis, Konstantinos
Fleischman, Debra A.
Grisot, Giorgia
Barth, Christopher M.
Varentsova, Anna
Morris, Martha C.
Barnes, Lisa L.
Bennett, David A.
author_sort Arfanakis, Konstantinos
collection PubMed
description The purpose of this study was to test the hypothesis that higher levels of systemic inflammation in a community sample of non-demented subjects older than seventy years of age are associated with reduced diffusion anisotropy in brain white matter and lower cognition. Ninety-five older persons without dementia underwent detailed clinical and cognitive evaluation and magnetic resonance imaging, including diffusion tensor imaging. Systemic inflammation was assessed with a composite measure of commonly used circulating inflammatory markers (C-reactive protein and tumor necrosis factor-alpha). Tract-based spatial statistics analyses demonstrated that diffusion anisotropy in the body and isthmus of the corpus callosum was negatively correlated with the composite measure of systemic inflammation, controlling for demographic, clinical and radiologic factors. Visuospatial ability was negatively correlated with systemic inflammation, and diffusion anisotropy in the body and isthmus of the corpus callosum was shown to mediate this association. The findings of the present study suggest that higher levels of systemic inflammation may be associated with lower microstructural integrity in the corpus callosum of non-demented elderly individuals, and this may partially explain the finding of reduced higher-order visual cognition in aging.
format Online
Article
Text
id pubmed-3753267
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-37532672013-08-29 Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition Arfanakis, Konstantinos Fleischman, Debra A. Grisot, Giorgia Barth, Christopher M. Varentsova, Anna Morris, Martha C. Barnes, Lisa L. Bennett, David A. PLoS One Research Article The purpose of this study was to test the hypothesis that higher levels of systemic inflammation in a community sample of non-demented subjects older than seventy years of age are associated with reduced diffusion anisotropy in brain white matter and lower cognition. Ninety-five older persons without dementia underwent detailed clinical and cognitive evaluation and magnetic resonance imaging, including diffusion tensor imaging. Systemic inflammation was assessed with a composite measure of commonly used circulating inflammatory markers (C-reactive protein and tumor necrosis factor-alpha). Tract-based spatial statistics analyses demonstrated that diffusion anisotropy in the body and isthmus of the corpus callosum was negatively correlated with the composite measure of systemic inflammation, controlling for demographic, clinical and radiologic factors. Visuospatial ability was negatively correlated with systemic inflammation, and diffusion anisotropy in the body and isthmus of the corpus callosum was shown to mediate this association. The findings of the present study suggest that higher levels of systemic inflammation may be associated with lower microstructural integrity in the corpus callosum of non-demented elderly individuals, and this may partially explain the finding of reduced higher-order visual cognition in aging. Public Library of Science 2013-08-26 /pmc/articles/PMC3753267/ /pubmed/23991174 http://dx.doi.org/10.1371/journal.pone.0073107 Text en © 2013 Arfanakis et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Arfanakis, Konstantinos
Fleischman, Debra A.
Grisot, Giorgia
Barth, Christopher M.
Varentsova, Anna
Morris, Martha C.
Barnes, Lisa L.
Bennett, David A.
Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title_full Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title_fullStr Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title_full_unstemmed Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title_short Systemic Inflammation in Non-Demented Elderly Human Subjects: Brain Microstructure and Cognition
title_sort systemic inflammation in non-demented elderly human subjects: brain microstructure and cognition
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753267/
https://www.ncbi.nlm.nih.gov/pubmed/23991174
http://dx.doi.org/10.1371/journal.pone.0073107
work_keys_str_mv AT arfanakiskonstantinos systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT fleischmandebraa systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT grisotgiorgia systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT barthchristopherm systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT varentsovaanna systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT morrismarthac systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT barneslisal systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition
AT bennettdavida systemicinflammationinnondementedelderlyhumansubjectsbrainmicrostructureandcognition