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IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells

CD4 T cells acquire functional properties including cytokine production upon antigenic stimulation through the T cell receptor (TCR) and differentiate into T helper (Th) cells. Th1 cells produce interferon (IFN)-γ and Th2 cells produce interleukin (IL)-4. Th1 and 2 cells utilize IFN-γ and IL-4 for f...

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Autores principales: Sharma, Archna, Berga-Bolanos, Rosa, Sultana, Dil Afroz, Sen, Jyoti Misra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753281/
https://www.ncbi.nlm.nih.gov/pubmed/23990998
http://dx.doi.org/10.1371/journal.pone.0071872
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author Sharma, Archna
Berga-Bolanos, Rosa
Sultana, Dil Afroz
Sen, Jyoti Misra
author_facet Sharma, Archna
Berga-Bolanos, Rosa
Sultana, Dil Afroz
Sen, Jyoti Misra
author_sort Sharma, Archna
collection PubMed
description CD4 T cells acquire functional properties including cytokine production upon antigenic stimulation through the T cell receptor (TCR) and differentiate into T helper (Th) cells. Th1 cells produce interferon (IFN)-γ and Th2 cells produce interleukin (IL)-4. Th1 and 2 cells utilize IFN-γ and IL-4 for further maturation and maintenance, respectively. Promyelocytic leukemia zinc finger (PLZF)-expressing invariant natural killer T (iNKT) cells develop in the thymus and acquire functional ability to produce IL-4 and IFN-γ in the thymus in the absence of antigenic stimulation. In response to antigenic stimulation, iNKT cells rapidly produce IFN-γ and IL-4. However, it is still unknown as to whether iNKT cells require these cytokines for maturation or survival in vivo. In this study, using IL-4- and IL-4 receptor- (IL-4R) deficient mice, we demonstrate that IL-4 as well as IL-4R expression is dispensable for the development, function and maintenance of iNKT cells.
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spelling pubmed-37532812013-08-29 IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells Sharma, Archna Berga-Bolanos, Rosa Sultana, Dil Afroz Sen, Jyoti Misra PLoS One Research Article CD4 T cells acquire functional properties including cytokine production upon antigenic stimulation through the T cell receptor (TCR) and differentiate into T helper (Th) cells. Th1 cells produce interferon (IFN)-γ and Th2 cells produce interleukin (IL)-4. Th1 and 2 cells utilize IFN-γ and IL-4 for further maturation and maintenance, respectively. Promyelocytic leukemia zinc finger (PLZF)-expressing invariant natural killer T (iNKT) cells develop in the thymus and acquire functional ability to produce IL-4 and IFN-γ in the thymus in the absence of antigenic stimulation. In response to antigenic stimulation, iNKT cells rapidly produce IFN-γ and IL-4. However, it is still unknown as to whether iNKT cells require these cytokines for maturation or survival in vivo. In this study, using IL-4- and IL-4 receptor- (IL-4R) deficient mice, we demonstrate that IL-4 as well as IL-4R expression is dispensable for the development, function and maintenance of iNKT cells. Public Library of Science 2013-08-26 /pmc/articles/PMC3753281/ /pubmed/23990998 http://dx.doi.org/10.1371/journal.pone.0071872 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Sharma, Archna
Berga-Bolanos, Rosa
Sultana, Dil Afroz
Sen, Jyoti Misra
IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title_full IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title_fullStr IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title_full_unstemmed IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title_short IL-4 and IL-4 Receptor Expression Is Dispensable for the Development and Function of Natural Killer T Cells
title_sort il-4 and il-4 receptor expression is dispensable for the development and function of natural killer t cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753281/
https://www.ncbi.nlm.nih.gov/pubmed/23990998
http://dx.doi.org/10.1371/journal.pone.0071872
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