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Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reacti...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Basel
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753464/ https://www.ncbi.nlm.nih.gov/pubmed/23275944 http://dx.doi.org/10.1007/s00018-012-1239-3 |
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author | Cummins, Nathan W. Badley, Andrew D. |
author_facet | Cummins, Nathan W. Badley, Andrew D. |
author_sort | Cummins, Nathan W. |
collection | PubMed |
description | Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed. |
format | Online Article Text |
id | pubmed-3753464 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-37534642013-09-04 Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV Cummins, Nathan W. Badley, Andrew D. Cell Mol Life Sci Review Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed. Springer Basel 2012-12-30 2013 /pmc/articles/PMC3753464/ /pubmed/23275944 http://dx.doi.org/10.1007/s00018-012-1239-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Review Cummins, Nathan W. Badley, Andrew D. Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title_full | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title_fullStr | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title_full_unstemmed | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title_short | Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV |
title_sort | anti-apoptotic mechanisms of hiv: lessons and novel approaches to curing hiv |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753464/ https://www.ncbi.nlm.nih.gov/pubmed/23275944 http://dx.doi.org/10.1007/s00018-012-1239-3 |
work_keys_str_mv | AT cumminsnathanw antiapoptoticmechanismsofhivlessonsandnovelapproachestocuringhiv AT badleyandrewd antiapoptoticmechanismsofhivlessonsandnovelapproachestocuringhiv |