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Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV

Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reacti...

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Detalles Bibliográficos
Autores principales: Cummins, Nathan W., Badley, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753464/
https://www.ncbi.nlm.nih.gov/pubmed/23275944
http://dx.doi.org/10.1007/s00018-012-1239-3
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author Cummins, Nathan W.
Badley, Andrew D.
author_facet Cummins, Nathan W.
Badley, Andrew D.
author_sort Cummins, Nathan W.
collection PubMed
description Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed.
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spelling pubmed-37534642013-09-04 Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV Cummins, Nathan W. Badley, Andrew D. Cell Mol Life Sci Review Past efforts at curing infection with the human immunodeficiency virus (HIV) have been blocked by the resistance of some infected cells to viral cytopathic effects and the associated development of a latent viral reservoir. Furthermore, current efforts to clear the viral reservoir by means of reactivating latent virus are hampered by the lack of cell death in the newly productively infected cells. The purpose of this review is to describe the many anti-apoptotic mechanisms of HIV, as well as the current limitations in the field. Only by understanding how infected cells avoid HIV-induced cell death can an effective strategy to kill infected cells be developed. Springer Basel 2012-12-30 2013 /pmc/articles/PMC3753464/ /pubmed/23275944 http://dx.doi.org/10.1007/s00018-012-1239-3 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review
Cummins, Nathan W.
Badley, Andrew D.
Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title_full Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title_fullStr Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title_full_unstemmed Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title_short Anti-apoptotic mechanisms of HIV: lessons and novel approaches to curing HIV
title_sort anti-apoptotic mechanisms of hiv: lessons and novel approaches to curing hiv
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753464/
https://www.ncbi.nlm.nih.gov/pubmed/23275944
http://dx.doi.org/10.1007/s00018-012-1239-3
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