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Regulation of osteoclasts by membrane-derived lipid mediators

Osteoclasts are bone-resorbing cells of monocytic origin. An imbalance between bone formation and resorption can lead to osteoporosis or osteopetrosis. Osteoclastogenesis is triggered by RANKL- and IP3-induced Ca(2+) influx followed by activation of NFATc1, a master transcription factor for osteocla...

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Detalles Bibliográficos
Autores principales: Oikawa, Tsukasa, Kuroda, Yukiko, Matsuo, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Basel 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753467/
https://www.ncbi.nlm.nih.gov/pubmed/23296124
http://dx.doi.org/10.1007/s00018-012-1238-4