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LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition

The NLRP3 inflammasome is the most characterized inflammasome activated by cellular infection or stress, which is responsible for the maturation of proinflammatory cytokines IL-1β and IL-18. The precise molecular mechanism for negative regulation of NLRP3 inflammasome activation needs to be further...

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Detalles Bibliográficos
Autores principales:	Jin, Jing, Yu, Qian, Han, Chaofeng, Hu, Xiang, Xu, Sheng, Wang, Qingqing, Wang, Jianli, Li, Nan, Cao, Xuetao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753543/ https://www.ncbi.nlm.nih.gov/pubmed/23942110 http://dx.doi.org/10.1038/ncomms3075

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