Overexpression of Atg5 in mice activates autophagy and extends lifespan

Autophagy has been implicated in the ageing process, but whether autophagy activation extends lifespan in mammals is unknown. Here we show that ubiquitous overexpression of Atg5, a protein essential for autophagosome formation, extends median lifespan of mice by 17.2%. We demonstrate that moderate o...

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Detalles Bibliográficos
Autores principales: Pyo, Jong-Ok, Yoo, Seung-Min, Ahn, Hye-Hyun, Nah, Jihoon, Hong, Se-Hoon, Kam, Tae-In, Jung, Sunmin, Jung, Yong-Keun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753544/
https://www.ncbi.nlm.nih.gov/pubmed/23939249
http://dx.doi.org/10.1038/ncomms3300

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753544/
https://www.ncbi.nlm.nih.gov/pubmed/23939249
http://dx.doi.org/10.1038/ncomms3300

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