ATG5 is induced by DNA-damaging agents and promotes mitotic catastrophe independent of autophagy

Anticancer drug therapy activates both molecular cell death and autophagy pathways. Here we show that even sublethal concentrations of DNA-damaging drugs, such as etoposide and cisplatin, induce the expression of autophagy-related protein 5 (ATG5), which is both necessary and sufficient for the subs...

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Detalles Bibliográficos
Autores principales: Maskey, Dipak, Yousefi, Shida, Schmid, Inès, Zlobec, Inti, Perren, Aurel, Friis, Robert, Simon, Hans-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753548/
https://www.ncbi.nlm.nih.gov/pubmed/23945651
http://dx.doi.org/10.1038/ncomms3130

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753548/
https://www.ncbi.nlm.nih.gov/pubmed/23945651
http://dx.doi.org/10.1038/ncomms3130

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