Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis

Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated tha...

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Autores principales: Gubar, Olga, Morderer, Dmytro, Tsyba, Lyudmila, Croisé, Pauline, Houy, Sébastien, Ory, Stéphane, Gasman, Stéphane, Rynditch, Alla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753573/
https://www.ncbi.nlm.nih.gov/pubmed/23986746
http://dx.doi.org/10.3389/fendo.2013.00109
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author Gubar, Olga
Morderer, Dmytro
Tsyba, Lyudmila
Croisé, Pauline
Houy, Sébastien
Ory, Stéphane
Gasman, Stéphane
Rynditch, Alla
author_facet Gubar, Olga
Morderer, Dmytro
Tsyba, Lyudmila
Croisé, Pauline
Houy, Sébastien
Ory, Stéphane
Gasman, Stéphane
Rynditch, Alla
author_sort Gubar, Olga
collection PubMed
description Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells.
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spelling pubmed-37535732013-08-28 Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis Gubar, Olga Morderer, Dmytro Tsyba, Lyudmila Croisé, Pauline Houy, Sébastien Ory, Stéphane Gasman, Stéphane Rynditch, Alla Front Endocrinol (Lausanne) Endocrinology Intersectins (ITSNs) are a family of highly conserved proteins with orthologs from nematodes to mammals. In vertebrates, ITSNs are encoded by two genes (itsn1 and itsn2), which act as scaffolds that were initially discovered as proteins involved in endocytosis. Further investigation demonstrated that ITSN1 is also implicated in several other processes including regulated exocytosis, thereby suggesting a role for ITSN1 in the coupling between exocytosis and endocytosis in excitatory cells. Despite a high degree of conservation amongst orthologs, ITSN function is not so well preserved as they have acquired new properties during evolution. In this review, we will discuss the role of ITSN1 and its orthologs in exo- and endocytosis, in particular in neurons and neuroendocrine cells. Frontiers Media S.A. 2013-08-27 /pmc/articles/PMC3753573/ /pubmed/23986746 http://dx.doi.org/10.3389/fendo.2013.00109 Text en Copyright © 2013 Gubar, Morderer, Tsyba, Croisé, Houy, Ory, Gasman and Rynditch. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Gubar, Olga
Morderer, Dmytro
Tsyba, Lyudmila
Croisé, Pauline
Houy, Sébastien
Ory, Stéphane
Gasman, Stéphane
Rynditch, Alla
Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title_full Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title_fullStr Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title_full_unstemmed Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title_short Intersectin: The Crossroad between Vesicle Exocytosis and Endocytosis
title_sort intersectin: the crossroad between vesicle exocytosis and endocytosis
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753573/
https://www.ncbi.nlm.nih.gov/pubmed/23986746
http://dx.doi.org/10.3389/fendo.2013.00109
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