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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels

Kv11.1 channels are critical for the maintenance of a normal heart rhythm. The flow of potassium ions through these channels is controlled by two voltage-regulated gates, termed “activation” and “inactivation,” located at opposite ends of the pore. Crucially in Kv11.1 channels, inactivation gating o...

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Detalles Bibliográficos
Autores principales:	Perry, Matthew D., Wong, Sophia, Ng, Chai Ann, Vandenberg, Jamie I.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753607/ https://www.ncbi.nlm.nih.gov/pubmed/23980196 http://dx.doi.org/10.1085/jgp.201310975

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