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The Genome of Anopheles darlingi, the main neotropical malaria vector

Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World envir...

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Autores principales: Marinotti, Osvaldo, Cerqueira, Gustavo C., de Almeida, Luiz Gonzaga Paula, Ferro, Maria Inês Tiraboschi, Loreto, Elgion Lucio da Silva, Zaha, Arnaldo, Teixeira, Santuza M. R., Wespiser, Adam R., Almeida e Silva, Alexandre, Schlindwein, Aline Daiane, Pacheco, Ana Carolina Landim, da Silva, Artur Luiz da Costa, Graveley, Brenton R., Walenz, Brian P., Lima, Bruna de Araujo, Ribeiro, Carlos Alexandre Gomes, Nunes-Silva, Carlos Gustavo, de Carvalho, Carlos Roberto, Soares, Célia Maria de Almeida, de Menezes, Claudia Beatriz Afonso, Matiolli, Cleverson, Caffrey, Daniel, Araújo, Demetrius Antonio M., de Oliveira, Diana Magalhães, Golenbock, Douglas, Grisard, Edmundo Carlos, Fantinatti-Garboggini, Fabiana, de Carvalho, Fabíola Marques, Barcellos, Fernando Gomes, Prosdocimi, Francisco, May, Gemma, de Azevedo Junior, Gilson Martins, Guimarães, Giselle Moura, Goldman, Gustavo Henrique, Padilha, Itácio Q. M., Batista, Jacqueline da Silva, Ferro, Jesus Aparecido, Ribeiro, José M. C., Fietto, Juliana Lopes Rangel, Dabbas, Karina Maia, Cerdeira, Louise, Agnez-Lima, Lucymara Fassarella, Brocchi, Marcelo, de Carvalho, Marcos Oliveira, Teixeira, Marcus de Melo, Diniz Maia, Maria de Mascena, Goldman, Maria Helena S., Cruz Schneider, Maria Paula, Felipe, Maria Sueli Soares, Hungria, Mariangela, Nicolás, Marisa Fabiana, Pereira, Maristela, Montes, Martín Alejandro, Cantão, Maurício E., Vincentz, Michel, Rafael, Miriam Silva, Silverman, Neal, Stoco, Patrícia Hermes, Souza, Rangel Celso, Vicentini, Renato, Gazzinelli, Ricardo Tostes, Neves, Rogério de Oliveira, Silva, Rosane, Astolfi-Filho, Spartaco, Maciel, Talles Eduardo Ferreira, Ürményi, Turán P., Tadei, Wanderli Pedro, Camargo, Erney Plessmann, de Vasconcelos, Ana Tereza Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753621/
https://www.ncbi.nlm.nih.gov/pubmed/23761445
http://dx.doi.org/10.1093/nar/gkt484
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author Marinotti, Osvaldo
Cerqueira, Gustavo C.
de Almeida, Luiz Gonzaga Paula
Ferro, Maria Inês Tiraboschi
Loreto, Elgion Lucio da Silva
Zaha, Arnaldo
Teixeira, Santuza M. R.
Wespiser, Adam R.
Almeida e Silva, Alexandre
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
da Silva, Artur Luiz da Costa
Graveley, Brenton R.
Walenz, Brian P.
Lima, Bruna de Araujo
Ribeiro, Carlos Alexandre Gomes
Nunes-Silva, Carlos Gustavo
de Carvalho, Carlos Roberto
Soares, Célia Maria de Almeida
de Menezes, Claudia Beatriz Afonso
Matiolli, Cleverson
Caffrey, Daniel
Araújo, Demetrius Antonio M.
de Oliveira, Diana Magalhães
Golenbock, Douglas
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
de Carvalho, Fabíola Marques
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
de Azevedo Junior, Gilson Martins
Guimarães, Giselle Moura
Goldman, Gustavo Henrique
Padilha, Itácio Q. M.
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, José M. C.
Fietto, Juliana Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise
Agnez-Lima, Lucymara Fassarella
Brocchi, Marcelo
de Carvalho, Marcos Oliveira
Teixeira, Marcus de Melo
Diniz Maia, Maria de Mascena
Goldman, Maria Helena S.
Cruz Schneider, Maria Paula
Felipe, Maria Sueli Soares
Hungria, Mariangela
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martín Alejandro
Cantão, Maurício E.
Vincentz, Michel
Rafael, Miriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Vicentini, Renato
Gazzinelli, Ricardo Tostes
Neves, Rogério de Oliveira
Silva, Rosane
Astolfi-Filho, Spartaco
Maciel, Talles Eduardo Ferreira
Ürményi, Turán P.
Tadei, Wanderli Pedro
Camargo, Erney Plessmann
de Vasconcelos, Ana Tereza Ribeiro
author_facet Marinotti, Osvaldo
Cerqueira, Gustavo C.
de Almeida, Luiz Gonzaga Paula
Ferro, Maria Inês Tiraboschi
Loreto, Elgion Lucio da Silva
Zaha, Arnaldo
Teixeira, Santuza M. R.
Wespiser, Adam R.
Almeida e Silva, Alexandre
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
da Silva, Artur Luiz da Costa
Graveley, Brenton R.
Walenz, Brian P.
Lima, Bruna de Araujo
Ribeiro, Carlos Alexandre Gomes
Nunes-Silva, Carlos Gustavo
de Carvalho, Carlos Roberto
Soares, Célia Maria de Almeida
de Menezes, Claudia Beatriz Afonso
Matiolli, Cleverson
Caffrey, Daniel
Araújo, Demetrius Antonio M.
de Oliveira, Diana Magalhães
Golenbock, Douglas
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
de Carvalho, Fabíola Marques
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
de Azevedo Junior, Gilson Martins
Guimarães, Giselle Moura
Goldman, Gustavo Henrique
Padilha, Itácio Q. M.
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, José M. C.
Fietto, Juliana Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise
Agnez-Lima, Lucymara Fassarella
Brocchi, Marcelo
de Carvalho, Marcos Oliveira
Teixeira, Marcus de Melo
Diniz Maia, Maria de Mascena
Goldman, Maria Helena S.
Cruz Schneider, Maria Paula
Felipe, Maria Sueli Soares
Hungria, Mariangela
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martín Alejandro
Cantão, Maurício E.
Vincentz, Michel
Rafael, Miriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Vicentini, Renato
Gazzinelli, Ricardo Tostes
Neves, Rogério de Oliveira
Silva, Rosane
Astolfi-Filho, Spartaco
Maciel, Talles Eduardo Ferreira
Ürményi, Turán P.
Tadei, Wanderli Pedro
Camargo, Erney Plessmann
de Vasconcelos, Ana Tereza Ribeiro
author_sort Marinotti, Osvaldo
collection PubMed
description Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector–human and vector–parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi.
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spelling pubmed-37536212013-08-27 The Genome of Anopheles darlingi, the main neotropical malaria vector Marinotti, Osvaldo Cerqueira, Gustavo C. de Almeida, Luiz Gonzaga Paula Ferro, Maria Inês Tiraboschi Loreto, Elgion Lucio da Silva Zaha, Arnaldo Teixeira, Santuza M. R. Wespiser, Adam R. Almeida e Silva, Alexandre Schlindwein, Aline Daiane Pacheco, Ana Carolina Landim da Silva, Artur Luiz da Costa Graveley, Brenton R. Walenz, Brian P. Lima, Bruna de Araujo Ribeiro, Carlos Alexandre Gomes Nunes-Silva, Carlos Gustavo de Carvalho, Carlos Roberto Soares, Célia Maria de Almeida de Menezes, Claudia Beatriz Afonso Matiolli, Cleverson Caffrey, Daniel Araújo, Demetrius Antonio M. de Oliveira, Diana Magalhães Golenbock, Douglas Grisard, Edmundo Carlos Fantinatti-Garboggini, Fabiana de Carvalho, Fabíola Marques Barcellos, Fernando Gomes Prosdocimi, Francisco May, Gemma de Azevedo Junior, Gilson Martins Guimarães, Giselle Moura Goldman, Gustavo Henrique Padilha, Itácio Q. M. Batista, Jacqueline da Silva Ferro, Jesus Aparecido Ribeiro, José M. C. Fietto, Juliana Lopes Rangel Dabbas, Karina Maia Cerdeira, Louise Agnez-Lima, Lucymara Fassarella Brocchi, Marcelo de Carvalho, Marcos Oliveira Teixeira, Marcus de Melo Diniz Maia, Maria de Mascena Goldman, Maria Helena S. Cruz Schneider, Maria Paula Felipe, Maria Sueli Soares Hungria, Mariangela Nicolás, Marisa Fabiana Pereira, Maristela Montes, Martín Alejandro Cantão, Maurício E. Vincentz, Michel Rafael, Miriam Silva Silverman, Neal Stoco, Patrícia Hermes Souza, Rangel Celso Vicentini, Renato Gazzinelli, Ricardo Tostes Neves, Rogério de Oliveira Silva, Rosane Astolfi-Filho, Spartaco Maciel, Talles Eduardo Ferreira Ürményi, Turán P. Tadei, Wanderli Pedro Camargo, Erney Plessmann de Vasconcelos, Ana Tereza Ribeiro Nucleic Acids Res Genomics Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors ∼100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector–human and vector–parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index.php/anopheles-darlingi. Oxford University Press 2013-08 2013-06-12 /pmc/articles/PMC3753621/ /pubmed/23761445 http://dx.doi.org/10.1093/nar/gkt484 Text en © The Author(s) 2013. Published by Oxford University Press. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Genomics
Marinotti, Osvaldo
Cerqueira, Gustavo C.
de Almeida, Luiz Gonzaga Paula
Ferro, Maria Inês Tiraboschi
Loreto, Elgion Lucio da Silva
Zaha, Arnaldo
Teixeira, Santuza M. R.
Wespiser, Adam R.
Almeida e Silva, Alexandre
Schlindwein, Aline Daiane
Pacheco, Ana Carolina Landim
da Silva, Artur Luiz da Costa
Graveley, Brenton R.
Walenz, Brian P.
Lima, Bruna de Araujo
Ribeiro, Carlos Alexandre Gomes
Nunes-Silva, Carlos Gustavo
de Carvalho, Carlos Roberto
Soares, Célia Maria de Almeida
de Menezes, Claudia Beatriz Afonso
Matiolli, Cleverson
Caffrey, Daniel
Araújo, Demetrius Antonio M.
de Oliveira, Diana Magalhães
Golenbock, Douglas
Grisard, Edmundo Carlos
Fantinatti-Garboggini, Fabiana
de Carvalho, Fabíola Marques
Barcellos, Fernando Gomes
Prosdocimi, Francisco
May, Gemma
de Azevedo Junior, Gilson Martins
Guimarães, Giselle Moura
Goldman, Gustavo Henrique
Padilha, Itácio Q. M.
Batista, Jacqueline da Silva
Ferro, Jesus Aparecido
Ribeiro, José M. C.
Fietto, Juliana Lopes Rangel
Dabbas, Karina Maia
Cerdeira, Louise
Agnez-Lima, Lucymara Fassarella
Brocchi, Marcelo
de Carvalho, Marcos Oliveira
Teixeira, Marcus de Melo
Diniz Maia, Maria de Mascena
Goldman, Maria Helena S.
Cruz Schneider, Maria Paula
Felipe, Maria Sueli Soares
Hungria, Mariangela
Nicolás, Marisa Fabiana
Pereira, Maristela
Montes, Martín Alejandro
Cantão, Maurício E.
Vincentz, Michel
Rafael, Miriam Silva
Silverman, Neal
Stoco, Patrícia Hermes
Souza, Rangel Celso
Vicentini, Renato
Gazzinelli, Ricardo Tostes
Neves, Rogério de Oliveira
Silva, Rosane
Astolfi-Filho, Spartaco
Maciel, Talles Eduardo Ferreira
Ürményi, Turán P.
Tadei, Wanderli Pedro
Camargo, Erney Plessmann
de Vasconcelos, Ana Tereza Ribeiro
The Genome of Anopheles darlingi, the main neotropical malaria vector
title The Genome of Anopheles darlingi, the main neotropical malaria vector
title_full The Genome of Anopheles darlingi, the main neotropical malaria vector
title_fullStr The Genome of Anopheles darlingi, the main neotropical malaria vector
title_full_unstemmed The Genome of Anopheles darlingi, the main neotropical malaria vector
title_short The Genome of Anopheles darlingi, the main neotropical malaria vector
title_sort genome of anopheles darlingi, the main neotropical malaria vector
topic Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753621/
https://www.ncbi.nlm.nih.gov/pubmed/23761445
http://dx.doi.org/10.1093/nar/gkt484
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AT gazzinelliricardotostes genomeofanophelesdarlingithemainneotropicalmalariavector
AT nevesrogeriodeoliveira genomeofanophelesdarlingithemainneotropicalmalariavector
AT silvarosane genomeofanophelesdarlingithemainneotropicalmalariavector
AT astolfifilhospartaco genomeofanophelesdarlingithemainneotropicalmalariavector
AT macieltalleseduardoferreira genomeofanophelesdarlingithemainneotropicalmalariavector
AT urmenyituranp genomeofanophelesdarlingithemainneotropicalmalariavector
AT tadeiwanderlipedro genomeofanophelesdarlingithemainneotropicalmalariavector
AT camargoerneyplessmann genomeofanophelesdarlingithemainneotropicalmalariavector
AT devasconcelosanaterezaribeiro genomeofanophelesdarlingithemainneotropicalmalariavector