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DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts

Sperm chromatin incubated in Xenopus egg extracts undergoes origin licensing and nuclear assembly before DNA replication. We found that depletion of DNA topoisomerase IIα (topo IIα), the sole topo II isozyme of eggs and its inhibition by ICRF-193, which clamps topo IIα around DNA have opposite effec...

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Detalles Bibliográficos
Autores principales:	Gaggioli, Vincent, Le Viet, Barbara, Germe, Thomas, Hyrien, Olivier
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753627/ https://www.ncbi.nlm.nih.gov/pubmed/23757188 http://dx.doi.org/10.1093/nar/gkt494

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