Carboxyl terminal domain basic amino acids of mycobacterial topoisomerase I bind DNA to promote strand passage

Bacterial DNA topoisomerase I (topoI) carries out relaxation of negatively supercoiled DNA through a series of orchestrated steps, DNA binding, cleavage, strand passage and religation. The N-terminal domain (NTD) of the type IA topoisomerases harbor DNA cleavage and religation activities, but the ca...

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Detalles Bibliográficos
Autores principales: Ahmed, Wareed, Bhat, Anuradha Gopal, Leelaram, Majety Naga, Menon, Shruti, Nagaraja, Valakunja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753633/
https://www.ncbi.nlm.nih.gov/pubmed/23771144
http://dx.doi.org/10.1093/nar/gkt506

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