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Programmable repression and activation of bacterial gene expression using an engineered CRISPR-Cas system

The ability to artificially control transcription is essential both to the study of gene function and to the construction of synthetic gene networks with desired properties. Cas9 is an RNA-guided double-stranded DNA nuclease that participates in the CRISPR-Cas immune defense against prokaryotic viru...

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Detalles Bibliográficos
Autores principales:	Bikard, David, Jiang, Wenyan, Samai, Poulami, Hochschild, Ann, Zhang, Feng, Marraffini, Luciano A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2013
Materias:	Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753641/ https://www.ncbi.nlm.nih.gov/pubmed/23761437 http://dx.doi.org/10.1093/nar/gkt520

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