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Epigenetic Functions of Smchd1 Repress Gene Clusters on the Inactive X Chromosome and on Autosomes
The Smchd1 gene encodes a large protein with homology to the SMC family of proteins involved in chromosome condensation and cohesion. Previous studies have found that Smchd1 has an important role in CpG island (CGI) methylation on the inactive X chromosome (Xi) and in stable silencing of some Xi gen...
Autores principales: | Gendrel, Anne-Valerie, Tang, Y. Amy, Suzuki, Masako, Godwin, Jonathan, Nesterova, Tatyana B., Greally, John M., Heard, Edith, Brockdorff, Neil |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753908/ https://www.ncbi.nlm.nih.gov/pubmed/23754746 http://dx.doi.org/10.1128/MCB.00145-13 |
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