Uncoupling of Influenza A Virus Transcription and Replication through Mutation of the Unpaired Adenosine in the Viral RNA Promoter

Transcription and replication of the influenza A virus RNA genome are mediated by the viral RNA polymerase from a promoter consisting of the partially base-paired 3′ and 5′ termini of viral genome segments. Here we show that transcription and replication can be uncoupled by mutation of an unpaired a...

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Detalles Bibliográficos
Autores principales: te Velthuis, Aartjan J. W., Turrell, Lauren, Vreede, Frank T., Fodor, Ervin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2013
Materias:
Genome Replication and Regulation of Viral Gene Expression
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3753995/
https://www.ncbi.nlm.nih.gov/pubmed/23864616
http://dx.doi.org/10.1128/JVI.00636-13

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