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Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients wit...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Sociedade Brasileira de Dermatologia
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754365/ https://www.ncbi.nlm.nih.gov/pubmed/23793207 http://dx.doi.org/10.1590/abd1806-4841.20131532 |
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author | Criado, Paulo Ricardo Antinori, Lidi Che Leon Maruta, Celina Wakisaka dos Reis, Vitor Manoel Silva |
author_facet | Criado, Paulo Ricardo Antinori, Lidi Che Leon Maruta, Celina Wakisaka dos Reis, Vitor Manoel Silva |
author_sort | Criado, Paulo Ricardo |
collection | PubMed |
description | BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS: The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i) 12 patients with active chronic urticaria (CU); (ii) 10 patients with chronic urticaria under remission and (iii) 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes). Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA), and the result units were given in ng/ml FEU. RESULTS: Patients with active chronic urticaria had the highest serum levels of D-dimer (p<0.01), when compared to patients with CU under remission and the control group (patients with psoriasis). CONCLUSIONS: Patients with active chronic urticaria have higher serum levels of D-dimer, when compared to patients with chronic urticaria under remission and patients with psoriasis. We found elevated serum levels of D-dimer among patients with urticarial vasculitis. |
format | Online Article Text |
id | pubmed-3754365 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Sociedade Brasileira de Dermatologia |
record_format | MEDLINE/PubMed |
spelling | pubmed-37543652013-09-16 Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis* Criado, Paulo Ricardo Antinori, Lidi Che Leon Maruta, Celina Wakisaka dos Reis, Vitor Manoel Silva An Bras Dermatol Investigation BACKGROUND: It has been demonstrated that neutrophils, eosinophils and monocytes, under appropriated stimulus, may express tissue factor and therefore, activate the extrinsic pathway of coagulation. We performed a transversal and case-control study of patients with chronic urticaria and patients with psoriasis, in our outpatient clinic to evaluate the production of D-dimer. OBJECTIVE: To evaluate D-dimer serum levels in patients with chronic urticaria and its possible correlation with disease activity. PATIENTS AND METHODS: The study was conducted from October 2010 until March 2011. We selected 37 consecutive patients from our Allergy Unit and Psoriasis Unit, and divided them into three groups for statistical analysis: (i) 12 patients with active chronic urticaria (CU); (ii) 10 patients with chronic urticaria under remission and (iii) 15 patients with psoriasis (a disease with skin inflammatory infiltrate constituted by neutrophils, lymphocytes and monocytes). Another five patients with urticarial vasculitis were allocated in our study, but not included in statistical analysis. The serum levels of D-dimer were measured by Enzyme Linked Fluorescent Assay (ELFA), and the result units were given in ng/ml FEU. RESULTS: Patients with active chronic urticaria had the highest serum levels of D-dimer (p<0.01), when compared to patients with CU under remission and the control group (patients with psoriasis). CONCLUSIONS: Patients with active chronic urticaria have higher serum levels of D-dimer, when compared to patients with chronic urticaria under remission and patients with psoriasis. We found elevated serum levels of D-dimer among patients with urticarial vasculitis. Sociedade Brasileira de Dermatologia 2013 /pmc/articles/PMC3754365/ /pubmed/23793207 http://dx.doi.org/10.1590/abd1806-4841.20131532 Text en ©2013 by Anais Brasileiros de Dermatologia http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Investigation Criado, Paulo Ricardo Antinori, Lidi Che Leon Maruta, Celina Wakisaka dos Reis, Vitor Manoel Silva Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis* |
title | Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
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title_full | Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
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title_fullStr | Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
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title_full_unstemmed | Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
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title_short | Evaluation of D-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis*
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title_sort | evaluation of d-dimer serum levels among patients with chronic urticaria, psoriasis and urticarial vasculitis* |
topic | Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754365/ https://www.ncbi.nlm.nih.gov/pubmed/23793207 http://dx.doi.org/10.1590/abd1806-4841.20131532 |
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