HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.

Papillomavirus is the etiological agent for warts and several squamous carcinomas. Skin cancer induced by cottontail rabbit papillomavirus was the first animal model for virus-induced carcinogenesis. The target organ of the virus infection is stratified epithelium and virus replication is tightly re...

Descripción completa

Detalles Bibliográficos
Autores principales: Kajitani, Naoko, Satsuka, Ayano, Yoshida, Satoshi, Sakai, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754431/
https://www.ncbi.nlm.nih.gov/pubmed/23986755
http://dx.doi.org/10.3389/fmicb.2013.00251
_version_ 1782281907794345984
author Kajitani, Naoko
Satsuka, Ayano
Yoshida, Satoshi
Sakai, Hiroyuki
author_facet Kajitani, Naoko
Satsuka, Ayano
Yoshida, Satoshi
Sakai, Hiroyuki
author_sort Kajitani, Naoko
collection PubMed
description Papillomavirus is the etiological agent for warts and several squamous carcinomas. Skin cancer induced by cottontail rabbit papillomavirus was the first animal model for virus-induced carcinogenesis. The target organ of the virus infection is stratified epithelium and virus replication is tightly regulated by the differentiation program of the host cell. E1^E4 protein is a viral gene product, and although it is considered to be involved in the control of virus replication, little is known about the biological role. We found that HPV18 E1^E4 was assembled into an aggresome-like compartment and was involved in sequestration of virus oncoproteins, which might contribute to the differentiation-dependent lifecycle of papillomavirus.
format Online
Article
Text
id pubmed-3754431
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-37544312013-08-28 HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins. Kajitani, Naoko Satsuka, Ayano Yoshida, Satoshi Sakai, Hiroyuki Front Microbiol Microbiology Papillomavirus is the etiological agent for warts and several squamous carcinomas. Skin cancer induced by cottontail rabbit papillomavirus was the first animal model for virus-induced carcinogenesis. The target organ of the virus infection is stratified epithelium and virus replication is tightly regulated by the differentiation program of the host cell. E1^E4 protein is a viral gene product, and although it is considered to be involved in the control of virus replication, little is known about the biological role. We found that HPV18 E1^E4 was assembled into an aggresome-like compartment and was involved in sequestration of virus oncoproteins, which might contribute to the differentiation-dependent lifecycle of papillomavirus. Frontiers Media S.A. 2013-08-27 /pmc/articles/PMC3754431/ /pubmed/23986755 http://dx.doi.org/10.3389/fmicb.2013.00251 Text en Copyright © Kajitani, Satsuka, Yoshida and Sakai. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Kajitani, Naoko
Satsuka, Ayano
Yoshida, Satoshi
Sakai, Hiroyuki
HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title_full HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title_fullStr HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title_full_unstemmed HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title_short HPV18 E1^E4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
title_sort hpv18 e1^e4 is assembled into aggresome-like compartment and involved in sequestration of viral oncoproteins.
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754431/
https://www.ncbi.nlm.nih.gov/pubmed/23986755
http://dx.doi.org/10.3389/fmicb.2013.00251
work_keys_str_mv AT kajitaninaoko hpv18e1e4isassembledintoaggresomelikecompartmentandinvolvedinsequestrationofviraloncoproteins
AT satsukaayano hpv18e1e4isassembledintoaggresomelikecompartmentandinvolvedinsequestrationofviraloncoproteins
AT yoshidasatoshi hpv18e1e4isassembledintoaggresomelikecompartmentandinvolvedinsequestrationofviraloncoproteins
AT sakaihiroyuki hpv18e1e4isassembledintoaggresomelikecompartmentandinvolvedinsequestrationofviraloncoproteins

Ejemplares similares