Cargando…

Coreceptor affinity for MHC defines peptide specificity requirements for TCR interaction with coagonist peptide–MHC

Recent work has demonstrated that nonstimulatory endogenous peptides can enhance T cell recognition of antigen, but MHCI- and MHCII-restricted systems have generated very different results. MHCII-restricted TCRs need to interact with the nonstimulatory peptide–MHC (pMHC), showing peptide specificity...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hoerter, John A.H., Brzostek, Joanna, Artyomov, Maxim N., Abel, Steven M., Casas, Javier, Rybakin, Vasily, Ampudia, Jeanette, Lotz, Carina, Connolly, Janet M., Chakraborty, Arup K., Gould, Keith G., Gascoigne, Nicholas R.J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754861/ https://www.ncbi.nlm.nih.gov/pubmed/23940257 http://dx.doi.org/10.1084/jem.20122528

Ejemplares similares

Ligand engaged TCR is triggered by Lck not associated with CD8 coreceptor
por: Casas, Javier, et al.
Publicado: (2014)

Negative Selection Assay Based on Stimulation of T Cell Receptor Transgenic Thymocytes with Peptide-MHC Tetramers
por: Rybakin, Vasily, et al.
Publicado: (2012)

Initiation of TCR Phosphorylation and Signal Transduction
por: Gascoigne, Nicholas R. J., et al.
Publicado: (2011)

T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state
por: Yachi, Pia P., et al.
Publicado: (2007)

Targeting CAR to the Peptide-MHC Complex Reveals Distinct Signaling Compared to That of TCR in a Jurkat T Cell Model
por: Wu, Ling, et al.
Publicado: (2021)

Nonstimulatory peptide–MHC enhances human T-cell antigen-specific responses by amplifying proximal TCR signaling
por: Zhao, Xiang, et al.
Publicado: (2018)

Targeting cancers through TCR-peptide/MHC interactions
por: He, Qinghua, et al.
Publicado: (2019)

Non-Stimulatory pMHC Enhance CD8 T Cell Effector Functions by Recruiting Coreceptor-Bound Lck
por: Zhao, Xiang, et al.
Publicado: (2021)

TCR‐induced alteration of primary MHC peptide anchor residue
por: Madura, Florian, et al.
Publicado: (2019)

Inherent reactivity of unselected TCR repertoires to peptide-MHC molecules
por: Krovi, S. Harsha, et al.
Publicado: (2019)

TCR Recognition of Peptide–MHC-I: Rule Makers and Breakers
por: Szeto, Christopher, et al.
Publicado: (2020)

Allelic Exclusion of TCR α-Chains upon Severe Restriction of Vα Repertoire
por: Rybakin, Vasily, et al.
Publicado: (2014)

Hybrid gMLP model for interaction prediction of MHC-peptide and TCR
por: Zhang, Lichao, et al.
Publicado: (2023)

T cell receptor (TCR) recognition of MHC class I variants: intermolecular second-site reversion provides evidence for peptide/MHC conformational variation
Publicado: (1996)

Structural Basis for the Restoration of TCR Recognition of an MHC Allelic Variant by Peptide Secondary Anchor Substitution
por: Miley, Michael J., et al.
Publicado: (2004)

Structural interplay between germline and adaptive recognition determines TCR-peptide-MHC cross-reactivity
por: Adams, Jarrett J., et al.
Publicado: (2015)

The coordination of unprotonated peptide tertiary structure as a metric of pMHC–TCR functional avidity
por: Antipas, Georgios S.E., et al.
Publicado: (2015)

Covalent TCR-peptide-MHC interactions induce T cell activation and redirect T cell fate in the thymus
por: Szeto, Christopher, et al.
Publicado: (2022)

Structural analysis of cancer-relevant TCR-CD3 and peptide-MHC complexes by cryoEM
por: Saotome, Kei, et al.
Publicado: (2023)

Themis sets the signal threshold for positive and negative selection in T-cell development
por: Fu, Guo, et al.
Publicado: (2013)

MetaMHC: a meta approach to predict peptides binding to MHC molecules
por: Hu, Xihao, et al.
Publicado: (2010)

Cell Type-Specific Regulation of Immunological Synapse Dynamics by B7 Ligand Recognition
por: Brzostek, Joanna, et al.
Publicado: (2016)

TCR–pMHC bond conformation controls TCR ligand discrimination
por: Sasmal, Dibyendu K., et al.
Publicado: (2019)

Suboptimal activation of melanoma infiltrating lymphocytes (TIL) due to low avidity of TCR/MHC-tumor peptide interactions
Publicado: (1996)

The TCR’s sensitivity to self-peptide–MHC dictates the ability of naïve CD8(+) T cells to respond to foreign antigens
por: Fulton, Ross B., et al.
Publicado: (2014)

TCR/pMHC Optimized Protein crystallization Screen
por: Bulek, Anna M., et al.
Publicado: (2012)

Targeting the MHC Ligandome by Use of TCR-Like Antibodies
por: Høydahl, Lene Støkken, et al.
Publicado: (2019)

Search for MHC/TCR-Like Systems in Living Organisms
por: Paganini, Julien, et al.
Publicado: (2021)

The Enigmatic Nature of the TCR-pMHC Interaction: Implications for CAR-T and TCR-T Engineering
por: Shevyrev, D. V., et al.
Publicado: (2022)

Restricted MHC–peptide repertoire predisposes to autoimmunity
por: Logunova, Nadezda N., et al.
Publicado: (2005)

SVRMHC prediction server for MHC-binding peptides
por: Wan, Ji, et al.
Publicado: (2006)

Olfactory imprinting is triggered by MHC peptide ligands
por: Hinz, Cornelia, et al.
Publicado: (2013)

Lck bound to coreceptor is less active than free Lck
por: Wei, Qianru, et al.
Publicado: (2020)

PAComplex: a web server to infer peptide antigen families and binding models from TCR–pMHC complexes
por: Liu, I-Hsin, et al.
Publicado: (2011)

Melanoma Peptide MHC Specific TCR Expressing T-Cell Membrane Camouflaged PLGA Nanoparticles for Treatment of Melanoma Skin Cancer
por: Yaman, Serkan, et al.
Publicado: (2020)

Expansion of an Unusual Virtual Memory CD8(+) Subpopulation Bearing Vα3.2 TCR in Themis-Deficient Mice
por: Prasad, Mukul, et al.
Publicado: (2021)

Coreceptors and TCR Signaling – the Strong and the Weak of It
por: Mørch, Alexander M., et al.
Publicado: (2020)

Donor major histocompatibility complex (MHC) peptides are presented by recipient MHC molecules during graft rejection
Publicado: (1992)

T cell receptor interaction with peptide/major histocompatibility complex (MHC) and superantigen/MHC ligands is dominated by antigen
Publicado: (1993)

Dynamically Driven Allostery in MHC Proteins: Peptide-Dependent Tuning of Class I MHC Global Flexibility
por: Ayres, Cory M., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_2u06q13cfl24etlhp9knei2tej