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Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown dependence on expression of the inhibitory FcγR, FcγRIIB. It remains unclear if enga...

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Detalles Bibliográficos
Autores principales:	Bulliard, Yannick, Jolicoeur, Rose, Windman, Maurice, Rue, Sarah M., Ettenberg, Seth, Knee, Deborah A., Wilson, Nicholas S., Dranoff, Glenn, Brogdon, Jennifer L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Brief Definitive Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754864/ https://www.ncbi.nlm.nih.gov/pubmed/23897982 http://dx.doi.org/10.1084/jem.20130573

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