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Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth
Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates that these lipid-signaling molecules can have pl...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754867/ https://www.ncbi.nlm.nih.gov/pubmed/23980123 http://dx.doi.org/10.1084/jem.20131335 |
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author | York, Autumn G. Bensinger, Steven J. |
author_facet | York, Autumn G. Bensinger, Steven J. |
author_sort | York, Autumn G. |
collection | PubMed |
description | Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates that these lipid-signaling molecules can have pleiotropic effects on the fate and function of the immune system. These effects range from the regulation of immune cell survival and proliferation to chemotaxis and antiviral immunity. New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic neutrophils into the tumor microenvironment. The consequence of this recruitment is the generation of proangiogenic factors and matrix metalloproteinase proteins that provide a tumor a significant growth and survival advantage. In combination with other recent studies, these data highlight the ongoing cross talk between sterol metabolism and the immune system, and they raise the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic approach in the war on cancer. |
format | Online Article Text |
id | pubmed-3754867 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-37548672014-02-26 Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth York, Autumn G. Bensinger, Steven J. J Exp Med Minireview Oxysterols are oxidized derivatives of cholesterol that are generated enzymatically or through autoxidation. Initially identified as important lipid signaling molecules in the context of atherosclerosis and inflammation, accumulated evidence indicates that these lipid-signaling molecules can have pleiotropic effects on the fate and function of the immune system. These effects range from the regulation of immune cell survival and proliferation to chemotaxis and antiviral immunity. New studies now indicate that tumor-derived oxysterols can serve to subvert the immune system by recruiting protumorigenic neutrophils into the tumor microenvironment. The consequence of this recruitment is the generation of proangiogenic factors and matrix metalloproteinase proteins that provide a tumor a significant growth and survival advantage. In combination with other recent studies, these data highlight the ongoing cross talk between sterol metabolism and the immune system, and they raise the intriguing possibility that targeting oxysterol pathways could serve as a novel therapeutic approach in the war on cancer. The Rockefeller University Press 2013-08-26 /pmc/articles/PMC3754867/ /pubmed/23980123 http://dx.doi.org/10.1084/jem.20131335 Text en © 2013 York and Bensinger This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/). |
spellingShingle | Minireview York, Autumn G. Bensinger, Steven J. Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title | Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title_full | Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title_fullStr | Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title_full_unstemmed | Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title_short | Subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
title_sort | subverting sterols: rerouting an oxysterol-signaling pathway to promote tumor growth |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3754867/ https://www.ncbi.nlm.nih.gov/pubmed/23980123 http://dx.doi.org/10.1084/jem.20131335 |
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